Bidirectional association between systemic lupus erythematosus and macrophage activation syndrome: a nationwide population-based study

doi:10.1093/rheumatology/keab502

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23462

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23462

Title:	Bidirectional association between systemic lupus erythematosus and macrophage activation syndrome: a nationwide population-based study
Authors:	Huang, LW;Wei, JCC;Chen, DY;Chen, YJ;Tang, KT;Ko, TM;Chen, HH
Keywords:	macrophage activation syndrome;SLE;autoimmune disease;NHIRD
Date:	2021
Issue Date:	2022-08-05T09:37:40Z (UTC)
Publisher:	OXFORD UNIV PRESS
ISSN:	1462-0324
Abstract:	Objectives To determine the bidirectional relationship between macrophage activation syndrome (MAS) and SLE . Methods Using the 1997-2013 Taiwan National Health Insurance Research Database, we identified patients with newly diagnosed SLE from 2001 to 2013 and selected individuals without SLE from a 1 million representative population. Propensity score (PS) matching was performed to balance incident SLE patients and individuals without SLE according to age, sex, comorbidities and medical utilization. The association between a history of MAS and SLE was studied using conditional logistic regression analysis shown as an adjusted odds ratio (aOR). The risk of MAS associated with SLE was analysed using Cox proportional regression analysis, shown as an adjusted hazard ratio (aHR), and we conducted a sensitivity analysis using various definitions of MAS. Results We included 10 481 SLE patients and 20 962 PS-matched (1:2) non-SLE individuals. The correlation between a history of MAS and SLE did not reach statistical significance after adjustment for potential confounders [aOR 1.18 (95% CI, 0.80, 1.75)] in the age-/sex-matched populations. In the 1:2 PS-matched populations, the risk of MAS markedly increased in patients with SLE [aHR 7.18 (95% CI 4.97, 10.36)]. Other risk factors for MAS included female gender, age >= 65 years, low income, a history of inflammatory bowel disease and a history of MAS. Conclusion This nationwide, population-based study revealed that a history of MAS was not significantly associated with SLE risk. However, the risk of MAS was markedly associated with SLE and a history of MAS.
URI:	http://dx.doi.org/10.1093/rheumatology/keab502 https://www.webofscience.com/wos/woscc/full-record/WOS:000755820300001 https://ir.csmu.edu.tw:8080/handle/310902500/23462
Relation:	RHEUMATOLOGY ,2022,v61,issue 3, P1123-1132
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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