Anticancer effects of picrasidine I on oral squamous cell carcinoma

doi:10.1002/tox.23430

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23450

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23450

Title:	Anticancer effects of picrasidine I on oral squamous cell carcinoma
Authors:	Yang, YT;Hsieh, MJ;Chuang, YC;Lin, CC;Lo, YS;Ho, HY;Kumar, VB;Ko, JL
Keywords:	apoptosis;JNK;oral cancer;Picrasidine I
Date:	2021
Issue Date:	2022-08-05T09:37:29Z (UTC)
Publisher:	WILEY
ISSN:	1520-4081
Abstract:	Picrasidine I is a dimeric alkaloid derived from a Southern Asian plant Picrasma quassioides and demonstrated to possess pharmacological activities, such as anti-inflammatory and anti-osteoclastogenic effects. However, its potential anticancer effect remains unclear. In the present study, anticancer activity of picrasidine I was assessed by treating oral squamous cell carcinoma cells with different concentrations of picrasidine I (20, 30, and 40 mu M) for 24, 48, and 72 h. The findings revealed that picrasidine I reduced the cell viability in a dose-dependent manner. Picrasidine I exerted its cytotoxic effect through arresting cell cycle at G2/M phase by downregulating cyclin A, cyclin B, CDK4, and CDK6, and inducing apoptosis in oral cancer cells. The induction of apoptosis was evidenced by increasing expression of death receptors, disruption of mitochondrial membrane potential, increased activation of PARP and caspases 3, 8, and 9, enhanced expression of proapoptotic mediators (Bak and Bim L/S), and reduced expression of antiapoptotic mediators (Bcl-2 and Bcl-xL). Moreover, analysis of MAPK signaling pathway revealed that picrasidine I-mediated proapoptotic activities by downregulating JNK phosphorylation. Taken together, the study identifies picrasidine I as a potent anticancer agent that can be used as a therapeutic intervention against oral squamous cell carcinoma.
URI:	http://dx.doi.org/10.1002/tox.23430 https://www.webofscience.com/wos/woscc/full-record/WOS:000729103000001 https://ir.csmu.edu.tw:8080/handle/310902500/23450
Relation:	ENVIRONMENTAL TOXICOLOGY ,2022,v37,issue 3, P627-636
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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