Predictors of early progression after curative resection followed by platinum-based adjuvant chemoradiotherapy in oral cavity squamous cell carcinoma

doi:10.1080/00325481.2020.1809869

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23443

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23443

Title:	Predictors of early progression after curative resection followed by platinum-based adjuvant chemoradiotherapy in oral cavity squamous cell carcinoma
Authors:	Lu, HJ;Tseng, SW;Peng, CY;Tseng, HC;Hsin, CH;Chen, HL;Huang, WS;Wu, MF;Yang, MH;Chang, PMH
Keywords:	Oral cavity squamous cell carcinoma;early progression;predictive markers;adjuvant chemoradiotherapy
Date:	2021
Issue Date:	2022-08-05T09:37:23Z (UTC)
Publisher:	TAYLOR & FRANCIS LTD
ISSN:	0032-5481
Abstract:	Objectives Early progression, defined as a disease-free interval (DFI) of less than 6 months after completion of adjuvant platinum-based chemoradiotherapy (CRT), leads to poor outcomes in locally advanced oral cavity squamous cell carcinoma (OCSCC). However, appropriate biomarkers for predicting early progression remain unknown. Methods In this study, 346 patients with OCSCC, who underwent curative surgical resection and platinum-based adjuvant CRT at the Taipei Veterans General Hospital (202 patients, training cohort) and Chung Shan Medical University Hospital (144 patients, validation cohort) were enrolled. The clinical-pathological variables were compared using the chi(2) test. Cox proportional-hazards analyses were performed for DFIs. Survival was estimated using the Kaplan-Meier method and log-rank tests, and a scoring system for predicting early progression was established. Results One-fifth (20.5%, 71/346) of all patients experienced progression within 6 months. Each of the independent factors for the DFI in the training cohort, including pT3-4, extracapsular spread, and perineural invasion, were assigned a score of one point to establish a scoring system. The 6-month DFIs of the low-risk (score 0-1), intermediate-risk (score 2), and high-risk (score 3) groups were 97.8%, 78.7%, and 35.7% and 88.2%, 77.6%, and 42.1% in the training and validation cohorts, respectively. If the cutoff level was >= 2 or <2, the sensitivity/specificity/area under the curve for the training and validation cohorts were 94.4%/56.1%/0.837, and 73.3%/56.6%/0.703, respectively. Conclusions The established scoring system effectively predicted early progression after adjuvant CRT for locally advanced OCSCC.
URI:	http://dx.doi.org/10.1080/00325481.2020.1809869 https://www.webofscience.com/wos/woscc/full-record/WOS:000640418200017 https://ir.csmu.edu.tw:8080/handle/310902500/23443
Relation:	POSTGRADUATE MEDICINE ,2021,v133,issue 3, P377-384
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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