中山醫學大學機構典藏 CSMUIR:Item 310902500/23440
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    题名: The Functional Vision Protection Effect of Danshensu via Dopamine D1 Receptors: In Vivo Study
    作者: Chen, YW;Huang, YP;Wu, PC;Chiang, WY;Wang, PH;Chen, BYE
    关键词: danshensu;retina;functional vision;visual contrast sensitivity function
    日期: 2021
    上传时间: 2022-08-05T09:37:20Z (UTC)
    出版者: MDPI
    摘要: Danshensu, a traditional herb-based active component (Salvia miltiorrhiza Bunge), has garnered attention, due to its safety, nutritional value, and antioxidant effects, along with cardiovascular-protective and neuroprotective abilities; however, its effect on the retinal tissues and functional vision has not been fully studied. The objective of this study was to analyze the protective effect of danshensu on retinal tissues and functional vision in vivo in a mouse model of light-induced retinal degeneration. High energy light-evoked visual damage was confirmed by the loss in structural tissue integrity in the retina accompanied by a decline in visual acuity and visual contrast sensitivity function (VCSF), whereas the retina tissue exhibited severe Muller cell gliosis. Although danshensu treatment did not particularly reduce light-evoked damage to the photoreceptors, it significantly prevented Muller cell gliosis. Danshensu exerted protective effects against light-evoked deterioration on low spatial frequency-based VCSF as determined by the behavioral optomotor reflex method. Additionally, the protective effect of danshensu on VCSF can be reversed and blocked by the injection of a dopamine D1 receptor antagonist (SCH 23390). This study demonstrated that the major functional vision promotional effect of danshensu in vivo was through the dopamine D1 receptors enhancement pathway, rather than the structural protection of the retinas.
    URI: http://dx.doi.org/10.3390/nu13030978
    https://www.webofscience.com/wos/woscc/full-record/WOS:000633993400001
    https://ir.csmu.edu.tw:8080/handle/310902500/23440
    關聯: NUTRIENTS ,2021,v13,issue 3
    显示于类别:[中山醫學大學研究成果] 期刊論文

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