The Functional Vision Protection Effect of Danshensu via Dopamine D1 Receptors: In Vivo Study

doi:10.3390/nu13030978

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23440

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23440

Title:	The Functional Vision Protection Effect of Danshensu via Dopamine D1 Receptors: In Vivo Study
Authors:	Chen, YW;Huang, YP;Wu, PC;Chiang, WY;Wang, PH;Chen, BYE
Keywords:	danshensu;retina;functional vision;visual contrast sensitivity function
Date:	2021
Issue Date:	2022-08-05T09:37:20Z (UTC)
Publisher:	MDPI
Abstract:	Danshensu, a traditional herb-based active component (Salvia miltiorrhiza Bunge), has garnered attention, due to its safety, nutritional value, and antioxidant effects, along with cardiovascular-protective and neuroprotective abilities; however, its effect on the retinal tissues and functional vision has not been fully studied. The objective of this study was to analyze the protective effect of danshensu on retinal tissues and functional vision in vivo in a mouse model of light-induced retinal degeneration. High energy light-evoked visual damage was confirmed by the loss in structural tissue integrity in the retina accompanied by a decline in visual acuity and visual contrast sensitivity function (VCSF), whereas the retina tissue exhibited severe Muller cell gliosis. Although danshensu treatment did not particularly reduce light-evoked damage to the photoreceptors, it significantly prevented Muller cell gliosis. Danshensu exerted protective effects against light-evoked deterioration on low spatial frequency-based VCSF as determined by the behavioral optomotor reflex method. Additionally, the protective effect of danshensu on VCSF can be reversed and blocked by the injection of a dopamine D1 receptor antagonist (SCH 23390). This study demonstrated that the major functional vision promotional effect of danshensu in vivo was through the dopamine D1 receptors enhancement pathway, rather than the structural protection of the retinas.
URI:	http://dx.doi.org/10.3390/nu13030978 https://www.webofscience.com/wos/woscc/full-record/WOS:000633993400001 https://ir.csmu.edu.tw:8080/handle/310902500/23440
Relation:	NUTRIENTS ,2021,v13,issue 3
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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