中山醫學大學機構典藏 CSMUIR:Item 310902500/23426
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    题名: Efficacy of Probiotic Milk Formula on Blood Lipid and Intestinal Function in Mild Hypercholesterolemic Volunteers: A Placebo-control, Randomized Clinical Trial
    作者: Chiu, HF;Fang, CY;Shen, YC;Venkatakrishnan, K;Wang, CK
    关键词: Probiotics;Cholesterol;Microbiota;Hypercholesterolemic;Fecal movement
    日期: 2021
    上传时间: 2022-08-05T09:37:05Z (UTC)
    出版者: SPRINGER
    ISSN: 1867-1306
    摘要: Several studies have reported that probiotics could modulate host lipid metabolism via altering the intestinal microbiota. Hence, the current study was aimed to assess the efficacy of a mixture of probiotic-contained milk formula (PMF) with three different bacterial strains [Lactobacillus acidophilus (La5), Lactobacillus casei (TMC), Bifidobacterium lactis (Bb12)] on lipid profile and intestinal function in healthy mild hypercholesterolemic volunteers. Totally, 40 healthy mild hypercholesterolemic subjects (180-220 mg/dL) were randomly assigned into two groups as placebo or experimental group. All the subjects were requested to drink either PMF (experimental) or skimmed milk drink formula-placebo (30 g mixed with 200 mL of water) for 10 weeks and continued by 2 weeks of the follow-up period. Supplementation of PMF for 10 weeks significantly improved (p < 0.05) the fecal weight, fecal movement (decreased fecal gastrointestinal passing time) by improving intestinal microbiota (increasing beneficial bacterial species like Lactobacillus, Bifidobacterium spp.), and lag time of low-density lipoprotein (LDL) oxidation. Also, intake of PMF substantially reduced (p < 0.05) the levels of total cholesterol (TC; 8.1%) and low-density lipoprotein cholesterol (LDL-c; 10.4%) and thus showcasing its cardioprotective efficacy. PMF considerably improves gastrointestinal function by modulating fecal movement, intestinal microbiota, and decrease cholesterol and might be helpful in the management of hypercholesterolemia.
    URI: http://dx.doi.org/10.1007/s12602-020-09728-6
    https://www.webofscience.com/wos/woscc/full-record/WOS:000605486100001
    https://ir.csmu.edu.tw:8080/handle/310902500/23426
    關聯: PROBIOTICS AND ANTIMICROBIAL PROTEINS ,2021,v13,issue 3, P624-632
    显示于类别:[中山醫學大學研究成果] 期刊論文

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