Predictors of hepatitis B and C virus reactivation in patients with psoriasis treated with biologic agents: a 9-year multicenter cohort study

doi:10.1016/j.jaad.2019.12.001

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23424

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23424

Title:	Predictors of hepatitis B and C virus reactivation in patients with psoriasis treated with biologic agents: a 9-year multicenter cohort study
Authors:	Chiu, HY;Chiu, YM;Liao, NFC;Chi, CC;Tsai, TF;Hsieh, CY;Hsieh, TY;Lai, KL;Chiu, TM;Wu, NL;Hui, RCY;Lee, CN;Wang, TS;Chen, PH;Yang, CC;Huang, YH
Keywords:	biologics;hepatitis B;hepatitis C;immunosuppressant;psoriasis;reactivation
Date:	2021
Issue Date:	2022-08-05T09:37:03Z (UTC)
Publisher:	MOSBY-ELSEVIER
ISSN:	0190-9622
Abstract:	Background: The increasing use of biologics is accompanied by a risk of hepatitis B (HBV) and C virus (HCV) reactivation. Objective: To determine the predictors of HBV and HCV reactivation in patients with psoriasis receiving biologics. Methods: This study screened 2060 patients with psoriasis (3562 treatment episodes) who were taking biologics from 2009 to 2018. There were 359 patients with psoriasis with HBV (561 treatment episodes) and 61 with HCV infection (112 treatment episodes). Results: During 8809 and 1522 person-months of follow-up, 88 treatment episodes for HBV involved HBV reactivation, and 14 episodes of HCV involved reactivation. The reactivation rate was significantly higher in treatment episodes of chronic HBV infection than in that of occult HBV (34.3% vs 3.2%, P = .001) and resolved HBV (34.3% vs 5.0%, P < .001). The multivariate analysis revealed that being hepatitis B surface antigen seropositive, being hepatitis B e-antigen seropositive, and tumor necrosis factor-alpha-inhibitor therapy were risk factors for HBV reactivation, whereas antiviral prophylaxis was effective in reducing the risk of HBV reactivation. No predictors were significantly associated with HCV reactivation. Limitations: Observational design and a lack of a comparison group. Conclusion: Patients with psoriasis on biologics have a risk of HBV and HCV reactivations, particularly those who are seropositive for hepatitis B surface antigen and hepatitis B e-antigen and undergoing tumor necrosis factor-alpha-inhibitor therapy.
URI:	http://dx.doi.org/10.1016/j.jaad.2019.12.001 https://www.webofscience.com/wos/woscc/full-record/WOS:000687299800014 https://ir.csmu.edu.tw:8080/handle/310902500/23424
Relation:	JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY ,2021,v85,issue 2, P337-344
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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