Association between lymphovascular invasion and oncological outcome in node-negative upper tract urothelial carcinoma with different stage

doi:10.1016/j.urolonc.2020.08.008

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23397

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23397

Title:	Association between lymphovascular invasion and oncological outcome in node-negative upper tract urothelial carcinoma with different stage
Authors:	Chen, CS;Lin, CY;Wang, CL;Wang, SS;Li, JR;Yang, CK;Cheng, CL;Chiu, KY;Yang, SF
Keywords:	Urothelial carcinoma;Upper tract;Node negative;Nephroureterectomy;Survival;Lymphovascular invasion
Date:	2021
Issue Date:	2022-08-05T09:36:38Z (UTC)
Publisher:	ELSEVIER SCIENCE INC
ISSN:	1078-1439
Abstract:	Objectives: To evaluate the prognostic impact of lymphovascular invasion (LVI) on node-negative upper tract urothelial carcinoma (UTUC) in patients treated with radical nephroureterectomy (RNU). Materials and methods: A retrospective study was performed in single tertiary referral center of middle Taiwan between 2001 and 2015. Seven hundred and twenty-eight patients were diagnosed of UTUC and underwent RNU with ipsilateral bladder cuff excision including 303 and 195 patients with N0 and Nx status respectively. LVI status was assessed as a prognostic factor for cancer-specific (CSS) and overall survival (OS) using univariate and multivariate Cox regression analysis. Results: LVI was observed in 82 patients (16.5%). LVI presentation associated with smoking status, advanced tumor stage, high tumor grade, positive surgical margin, and consequence lung/liver/bone metastasis. In the multivariate analysis, LVI was failed to predict CSS, OS, and disease-free survival (DFS) (hazard ratio [HR] [95% confidence interval [CI]: 1.07 [0.55-2.09], 1.05 [0.62-1.79], 1.15 [0.69-1.92], in CSS, OS, DFS, respectively). In the subgroup analysis of pT1-2 disease, the CSS, OS, and DFS were associated with LVI status (HR [95% CI]: 2.29 [0.44-11.84], 3.17 [1.16-8.67], 2.66 [1.04-6.79], in CSS, OS, DFS, respectively). In contrast, there was no difference in pT3 disease. Conclusion: In conclusion, LVI status was not associated with survival outcomes of node-negative UTUC in our study. The subgroup analysis showed different prognostic impacts of LVI status in node-negative UTUC with T1-2 and T3 stage. Further evidence to clarify the prognostic effect is needed to make LVI became a practical factor in clinical decision-making. (C) 2020 Elsevier Inc. All rights reserved.
URI:	http://dx.doi.org/10.1016/j.urolonc.2020.08.008 https://www.webofscience.com/wos/woscc/full-record/WOS:000610203400015 https://ir.csmu.edu.tw:8080/handle/310902500/23397
Relation:	UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS ,2021,v39,issue 2
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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