中山醫學大學機構典藏 CSMUIR:Item 310902500/23389
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23389


    题名: PEROXISOME-PROLIFERATOR ACTIVATOR RECEPTOR gamma IN MOUSE MODEL WITH MENINGOENCEPHALITIS CAUSED BY ANGIOSTRONGYLUS CANTONENSIS
    作者: Chen, KM;Peng, CY;Shyu, LY;Lan, KP;Lai, SC
    关键词: Angiostrongylus cantonensis;COX-2;iNOS;MMP-9;PPAR gamma
    日期: 2021
    上传时间: 2022-08-05T09:36:29Z (UTC)
    出版者: ALLEN PRESS INC
    ISSN: 0022-3395
    摘要: Peroxisome-proliferator activator receptor gamma (PPAR gamma) has an anti-inflammatory role that inhibits the nuclear factor-kappa B (NF-kappa B) pathway and regulates the expressions of pro-inflammatory proteins, whereas its role in parasitic meningoencephalitis remains unknown. In this study we investigated the role of PPAR gamma and related mechanisms in eosinophilic meningoencephalitis caused by the rat lungworm Angiostrongylus cantonensis. We observed increased protein NF-kappa B expression in mouse brain tissue using GW9662, which is the specific antagonist of PPAR gamma, in a mouse model of angiostrongyliasis. Then we investigated NF kappa B-related downstream proteins, such as COX-2, NOSs, and IL-1 beta, with Western blot or enzyme-linked immunosorbent assay and found that the protein expression was upregulated. The results of gelatin zymography also showed that the MMP-9 activities were upregulated. Treatment with GW9662 increased the permeability of the blood-brain barrier and the number of eosinophils in cerebrospinal fluid. These results suggested that in angiostrongyliasis, PPAR gamma may play an anti-inflammation role in many inflammatory mediators, including NOS-related oxidative stress, cytokines, and matrix metalloproteinase cascade by decreasing the NF-kappa B action.
    URI: http://dx.doi.org/10.1645/19-182
    https://www.webofscience.com/wos/woscc/full-record/WOS:000639028100001
    https://ir.csmu.edu.tw:8080/handle/310902500/23389
    關聯: JOURNAL OF PARASITOLOGY ,2021,v107,issue 2, P205-213
    显示于类别:[中山醫學大學研究成果] 期刊論文

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