PEROXISOME-PROLIFERATOR ACTIVATOR RECEPTOR gamma IN MOUSE MODEL WITH MENINGOENCEPHALITIS CAUSED BY ANGIOSTRONGYLUS CANTONENSIS

doi:10.1645/19-182

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23389

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23389

Title:	PEROXISOME-PROLIFERATOR ACTIVATOR RECEPTOR gamma IN MOUSE MODEL WITH MENINGOENCEPHALITIS CAUSED BY ANGIOSTRONGYLUS CANTONENSIS
Authors:	Chen, KM;Peng, CY;Shyu, LY;Lan, KP;Lai, SC
Keywords:	Angiostrongylus cantonensis;COX-2;iNOS;MMP-9;PPAR gamma
Date:	2021
Issue Date:	2022-08-05T09:36:29Z (UTC)
Publisher:	ALLEN PRESS INC
ISSN:	0022-3395
Abstract:	Peroxisome-proliferator activator receptor gamma (PPAR gamma) has an anti-inflammatory role that inhibits the nuclear factor-kappa B (NF-kappa B) pathway and regulates the expressions of pro-inflammatory proteins, whereas its role in parasitic meningoencephalitis remains unknown. In this study we investigated the role of PPAR gamma and related mechanisms in eosinophilic meningoencephalitis caused by the rat lungworm Angiostrongylus cantonensis. We observed increased protein NF-kappa B expression in mouse brain tissue using GW9662, which is the specific antagonist of PPAR gamma, in a mouse model of angiostrongyliasis. Then we investigated NF kappa B-related downstream proteins, such as COX-2, NOSs, and IL-1 beta, with Western blot or enzyme-linked immunosorbent assay and found that the protein expression was upregulated. The results of gelatin zymography also showed that the MMP-9 activities were upregulated. Treatment with GW9662 increased the permeability of the blood-brain barrier and the number of eosinophils in cerebrospinal fluid. These results suggested that in angiostrongyliasis, PPAR gamma may play an anti-inflammation role in many inflammatory mediators, including NOS-related oxidative stress, cytokines, and matrix metalloproteinase cascade by decreasing the NF-kappa B action.
URI:	http://dx.doi.org/10.1645/19-182 https://www.webofscience.com/wos/woscc/full-record/WOS:000639028100001 https://ir.csmu.edu.tw:8080/handle/310902500/23389
Relation:	JOURNAL OF PARASITOLOGY ,2021,v107,issue 2, P205-213
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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