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    Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23382


    Title: Characteristics and outcomes of second cancers in patients with childhood cancer: A report from the Taiwan Pediatric Oncology Group
    Authors: Ho, WL;Hung, GY;Yen, HJ;Yang, YL;Chang, HH;Lu, MY;Lin, KH;Chen, JS;Cheng, CN;Hung, IJ;Yang, CP;Chen, SH;Liu, HC;Yeh, TC;Hou, JY;Hsiao, CC;Sheen, JM;Chang, TT;Wong, TT;Miser, JS;Liu, YL;Chen, RL;Chen, BW;Peng, CT;Chang, TK;Wu, KH;Chang, YH;Wang, JL;Wang, SC;Lin, MT;Hu, FC;Jou, ST;Lin, DT
    Keywords: Childhood;Outcome;Primary cancer;Second cancer;Survival probability
    Date: 2021
    Issue Date: 2022-08-05T09:36:22Z (UTC)
    Publisher: ELSEVIER TAIWAN
    ISSN: 0929-6646
    Abstract: Background: Patients with childhood cancer are at increased risk for the development of second cancers. Methods: A national multicenter survey of second cancers conducted by the Taiwan Pediatric Oncology Group retrieved retrospective data from the database at the Children Cancer Foundation in Taiwan beginning in 1995. The characteristics of second cancers and associations of patient demographic and clinical characteristics with time to death due to a second cancer were analyzed. Results: We examined the records of 8782 patients with a primary cancer diagnosed between January 1, 1995 and December 31, 2013, and a total of 99 patients with a second cancer were identified. The most common type of second cancer was acute myeloid leukemia (n = 35), followed by acute lymphoblastic leukemia (n = 15), central nervous system (CNS) tumors (n = 15), and sarcomas (n = 10). Secondary hematological malignancies occurred earlier than other secondary cancers. The frequencies of second CNS tumors and second bone cancers and sarcomas were notably increased when prior radiation doses increased from zero, low dose to high dose. The overall 5-year survival of patients with a second cancer was poor (33.7%). Multivariate survival analysis revealed that the year of primary diagnosis <2002, secondary hematological malignancies, and age at second cancer diagnosis <9.3 years or >26.8 years increased the risk of death following second cancer. Conclusion: Children who develop a second cancer have an unfavorable outcome. Early detection and improved treatment for second cancers are needed. Copyright 2021, Formosan Medical Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
    URI: http://dx.doi.org/10.1016/j.jfma.2021.05.012
    https://www.webofscience.com/wos/woscc/full-record/WOS:000734007200014
    https://ir.csmu.edu.tw:8080/handle/310902500/23382
    Relation: JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION ,2022,v121,issue 1, P350-359
    Appears in Collections:[中山醫學大學研究成果] 期刊論文

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