Risk of cancer development in patients with keloids

doi:10.1038/s41598-021-88789-1

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23369

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23369

Title:	Risk of cancer development in patients with keloids
Authors:	Lu, YY;Tu, HP;Wu, CH;Hong, CH;Yang, KC;Yang, HJ;Chang, KL;Lee, CH
Date:	2021
Issue Date:	2022-08-05T09:36:10Z (UTC)
Publisher:	NATURE RESEARCH
ISSN:	2045-2322
Abstract:	Keloid is a skin disease characterized by exaggerated scar formation, excessive fibroblast proliferation, and excessive collagen deposition. Cancers commonly arise from a fibrotic microenvironment; e.g., hepatoma arises from liver cirrhosis, and oral cancers arise from submucosal fibrosis. As keloids are a prototypic fibroproliferative disease, this study investigated whether patients with keloids have an increased cancer risk. In a matched, population-based study, first 17,401 patients treated for keloids during 1998-2010 with 69,604 controls without keloids at a ratio of 1:4 were evaluated. The association between keloids and risk of cancer was estimated by logistic regression or Cox proportional hazard regression models after adjustment of covariates. In total, 893 first-time cases of cancer were identified in the 17,401 patients with keloids. The overall cancer risk was 1.49-fold higher in the keloids group compared to controls. Regarding specific cancers, the keloids group, had a significantly higher risk of skin cancer compared to controls (Relative risk=1.73). The relative risk for skin cancer was even higher for males with keloids (Relative risk=2.16). Further stratified analyses also revealed a significantly higher risk of developing pancreatic cancer in female patients with keloids compared to controls (Relative risk=2.19) after adjustment for known pancreatic cancer risk factors. This study indicates that patients with keloids have a higher than normal risk for several cancer types, especially skin cancers (both genders) and pancreatic cancer (females). Therefore, patients with keloids should undergo regular skin examinations, and females with keloids should regularly undergo abdominal ultrasonography.
URI:	http://dx.doi.org/10.1038/s41598-021-88789-1 https://www.webofscience.com/wos/woscc/full-record/WOS:000656499000011 https://ir.csmu.edu.tw:8080/handle/310902500/23369
Relation:	SCIENTIFIC REPORTS ,2021,v11,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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