Is insulin the preferred treatment in persons with type 2 diabetes and liver cirrhosis?

doi:10.1186/s12876-021-01773-x

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23367

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23367

Title:	Is insulin the preferred treatment in persons with type 2 diabetes and liver cirrhosis?
Authors:	Yen, FS;Lai, JN;Wei, JCC;Chiu, LT;Hsu, CC;Hou, MC;Hwu, CM
Keywords:	All-cause mortality;Hepatocellular carcinoma;Hepatic failure;Decompensated cirrhosis;Hypoglycemia
Date:	2021
Issue Date:	2022-08-05T09:36:08Z (UTC)
Publisher:	BMC
Abstract:	Background Insulin is highly recommended for diabetes management in persons with liver cirrhosis. However, few studies have evaluated its long-term effects in these persons. We conducted this study to compare the risks of mortality, liver-related complications, and cardiovascular events in persons with type 2 diabetes mellitus (T2DM) and compensated liver cirrhosis. Methods From January 1, 2000, to December 31, 2012, we selected 2047 insulin users and 4094 propensity score-matched nonusers from Taiwan's National Health Insurance Research Database. Cox proportional hazard models were used to assess the risks of outcomes. Results The mean follow-up time was 5.84 years. The death rate during the follow-up period was 5.28 and 4.07 per 100 person-years for insulin users and nonusers, respectively. In insulin users, the hazard ratios and 95% confidence intervals (CIs) of all-cause mortality, hepatocellular carcinoma, decompensated cirrhosis, hepatic failure, major cardiovascular events, and hypoglycemia were 1.31 (1.18-1.45), 1.18 (1.05-1.34), 1.53 (1.35-1.72), 1.26 (1.42-1.86), 1.41 (1.23-1.62), and 3.33 (2.45-4.53), respectively. Conclusions This retrospective cohort study indicated that among persons with T2DM and compensated liver cirrhosis, insulin users were associated with higher risks of death, liver-related complications, cardiovascular events, and hypoglycemia compared with insulin nonusers.
URI:	http://dx.doi.org/10.1186/s12876-021-01773-x https://www.webofscience.com/wos/woscc/full-record/WOS:000663032000004 https://ir.csmu.edu.tw:8080/handle/310902500/23367
Relation:	BMC GASTROENTEROLOGY ,2021,v21,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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