Long-term exposure to air pollution and the risk of developing sudden sensorineural hearing loss

doi:10.1186/s12967-021-03095-8

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23363

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23363

Title:	Long-term exposure to air pollution and the risk of developing sudden sensorineural hearing loss
Authors:	Tsai, SCS;Hsu, YC;Lai, JN;Chou, RH;Fan, HC;Lin, FCF;Zhang, RH;Lin, CL;Chang, KH
Keywords:	Air pollution;Sudden sensorineural hearing loss (SSNHL);Adjusted hazard ratio (aHR);National Health Insurance program
Date:	2021
Issue Date:	2022-08-05T09:36:05Z (UTC)
Publisher:	BMC
Abstract:	Background The association between exposure to air pollution and sudden sensorineural hearing loss (SSNHL) has not been extensively discussed in the literature. Therefore, we conducted this nationwide study to evaluate the risk of SSNHL in Taiwanese residents with exposure to air pollution. Methods We enrolled subjects aged older than 20 years with no history of SSNHL from 1998 to 2010, and followed up until developing SSNHL, withdrawn from the National Health Insurance program, and the end of the database (2011/12/31). The air quality data are managed by Taiwan Environmental Protection Administration. The annual concentrations of PM2.5, SO2, CO, NO, and NO2 from 1998 to 2010 were classified into the three levels according to tertiles. We calculated the annual average of pollutants from baseline until the end of the study, and classified into tertiles. The adjusted hazard ratio (aHR) was estimated by using the multivariate Cox proportional hazard model. Results When considered continuous air pollutants concentration, subjects who exposed with higher concentration of CO (aHR = 2.16, 95% CI 1.50-3.11), NO (aHR = 1.02, 95% CI 1.01-1.03), and NO2 (aHR = 1.02, 95% CI 1.01-1.04) developing significant higher risk of SSNHL. When classified air pollutants concentration into low, moderate and high level by tertiles, and selected low level as reference, patients exposed with moderate (aHR = 1.56, 95% CI 1.20-2.04) or high level (aHR = 1.33, 95% CI 1.01-1.75) of PM2.5 showed significant higher risk of developing SSNHL. Conclusion This study indicated an increased risk of SSNHL in residents with long-term exposure to air pollution. Nevertheless, further experimental, and clinical studies are needed to validate the study findings.
URI:	http://dx.doi.org/10.1186/s12967-021-03095-8 https://www.webofscience.com/wos/woscc/full-record/WOS:000706728000002 https://ir.csmu.edu.tw:8080/handle/310902500/23363
Relation:	JOURNAL OF TRANSLATIONAL MEDICINE ,2021,v19,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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