中山醫學大學機構典藏 CSMUIR:Item 310902500/23345
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 17905/22920 (78%)
造訪人次 : 7533808      線上人數 : 247
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋


    請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23345


    題名: The Anti-inflammatory Effects of the Bioactive Compounds Isolated from Alpinia officinarum Hance Mediated by the Suppression of NF-kappaB and MAPK Signaling
    作者: Li, CY;Cheng, SE;Wang, SH;Wu, JY;Hsieh, CW;Tsou, HK;Tsai, MS
    關鍵詞: Alpinia officinarum Hance extract;anti-inflammatory effects;curcumin;galangin;kaempferol;quercetin
    日期: 2021
    上傳時間: 2022-08-05T09:35:46Z (UTC)
    出版者: WOLTERS KLUWER MEDKNOW PUBLICATIONS
    ISSN: 0304-4920
    摘要: This study was designed to evaluate the anti-inflammatory effects of Alpinia officinarum Hance extract (AOE) and identify its main active ingredients. AOE was obtained using a 95% ethanol extraction method. Lipopolysaccharide (LPS) were used to induce an inflammatory response in RAW264.7 cells. The results showed that AOE exerts anti-inflammatory effects via inhibition of prostaglandin E2 secretion and cyclooxygenase -2 (COX-2) production. We further analyzed the components of AOE using high-performance liquid chromatography and found that AOE is comprised of several bioactive flavonoids including quercetin (Q), kaempferol (K), galangin (G), and curcumin (C). These four flavonoids effectively inhibited nitric oxide (NO), interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha production. Moreover, they reduced COX-2 and inducible NO synthase expressions via regulation of nuclear factor kappa-light-chain-enhancer of activated B cells and c-Jun N-terminal kinase signaling pathways. Furthermore, we compared and contrasted the anti-inflammatory effects and mechanisms of these four flavonoids at the same dose in the LPS-induced cell inflammation model. The results showed that C is the most effective inhibitor of LPS-induced NO production. However, only Q and K effectively attenuated LPS-induced extracellular signal-regulated kinase and p38 elevations. In conclusion, AOE and its major bioactive compounds exert anti-inflammatory effects on LPS-induced inflammation. As A. officinarum Hance is much cheaper than any of its four flavonoids, especially G, we suggest using AOE as an anti-inflammatory agent.
    URI: http://dx.doi.org/10.4103/CJP.CJP_81_20
    https://www.webofscience.com/wos/woscc/full-record/WOS:000624630800004
    https://ir.csmu.edu.tw:8080/handle/310902500/23345
    關聯: CHINESE JOURNAL OF PHYSIOLOGY ,2021,v64,issue 1, P32-42
    顯示於類別:[中山醫學大學研究成果] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML219檢視/開啟


    SFX Query

    在CSMUIR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋