Association of ADH1B polymorphism and alcohol consumption with increased risk of intracerebral hemorrhagic stroke

doi:10.1186/s12967-021-02904-4

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23342

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23342

Title:	Association of ADH1B polymorphism and alcohol consumption with increased risk of intracerebral hemorrhagic stroke
Authors:	Lin, CH;Nfor, ON;Ho, CC;Hsu, SY;Tantoh, DM;Liaw, YC;Daria, MR;Chen, CH;Liaw, YP
Keywords:	Cardiovascular disease;Stroke;Epidemiology
Date:	2021
Issue Date:	2022-08-05T09:35:44Z (UTC)
Publisher:	BMC
Abstract:	Background Alcohol consumption is one of the modifiable risk factors for intracerebral hemorrhage, which accounts for approximately 10-20% of all strokes worldwide. We evaluated the association of stroke with genetic polymorphisms in the alcohol metabolizing genes, alcohol dehydrogenase 1B (ADH1B, rs1229984) and aldehyde dehydrogenase 2 (ALDH2, rs671) genes based on alcohol consumption. Methods Data were available for 19,500 Taiwan Biobank (TWB) participants. We used logistic regression models to test for associations between genetic variants and stroke. Overall, there were 890 individuals with ischemic stroke, 70 with hemorrhagic stroke, and 16,837 control individuals. Participants with ischemic but not hemorrhagic stroke were older than their control individuals (mean +/- SE, 58.47 +/- 8.17 vs. 48.33 +/- 10.90 years, p < 0.0001). ALDH2 rs671 was not associated with either hemorrhagic or ischemic stroke among alcohol drinkers. However, the risk of developing hemorrhagic stroke was significantly higher among ADH1B rs1229984 TC + CC individuals who drank alcohol (odds ratio (OR), 4.85; 95% confidence interval (CI) 1.92-12.21). We found that the test for interaction was significant for alcohol exposure and rs1229984 genotypes (p for interaction = 0.016). Stratification by alcohol exposure and ADH1B rs1229984 genotypes showed that the risk of developing hemorrhagic stroke remained significantly higher among alcohol drinkers with TC + CC genotype relative to those with the TT genotype (OR, 4.43, 95% CI 1.19-16.52). Conclusions Our study suggests that the ADH1B rs1229984 TC + CC genotype and alcohol exposure of at least 150 ml/week may increase the risk of developing hemorrhagic stroke among Taiwanese adults.
URI:	http://dx.doi.org/10.1186/s12967-021-02904-4 https://www.webofscience.com/wos/woscc/full-record/WOS:000659149500001 https://ir.csmu.edu.tw:8080/handle/310902500/23342
Relation:	JOURNAL OF TRANSLATIONAL MEDICINE ,2021,v19,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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