中山醫學大學機構典藏 CSMUIR:Item 310902500/23341
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    题名: Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia with kinase fusions in Taiwan
    作者: Hsu, YC;Yu, CH;Chen, YM;Roberts, KG;Ni, YL;Lin, KH;Jou, ST;Lu, MY;Chen, SH;Wu, KH;Chang, HH;Lin, DT;Lin, SW;Lin, ZS;Chiu, WT;Chang, CC;Ho, BC;Mullighan, CG;Yu, SL;Yang, YL
    日期: 2021
    上传时间: 2022-08-05T09:35:43Z (UTC)
    出版者: NATURE RESEARCH
    ISSN: 2045-2322
    摘要: Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukaemia (ALL), a high-risk subtype characterised by genomic alterations that activate cytokine receptor and kinase signalling, is associated with inferior outcomes in most childhood ALL clinical trials. Half of the patients with Ph-like ALL have kinase rearrangements or fusions. We examined the frequency and spectrum of these fusions using a retrospective cohort of 212 newly diagnosed patients with childhood B-cell ALL. Samples without known chromosomal alterations were subject to multiplex reverse transcription polymerase chain reaction to identify known Ph-like kinase fusions. Immunoglobulin heavy chain locus (IGH) capture and kinase capture were applied to samples without known kinase fusions. We detected known kinase fusions in five of 212 patients, comprising E8F1-PDGFRB, ETV6-ABL1, ZC3HAV1-ABL2, EPOR-IGH, and CNTRL-ABL1. Two patients with P2RY8-CRLF2 were identified. Patients with non-Ph kinase fusions had inferior 5-year event-free survival and overall survival compared with patients with other common genetic alterations. The prevalence of non-Ph kinase fusions in our Taiwanese cohort was lower than that reported in Caucasian populations. Future clinical trials with tyrosine kinase inhibitors may be indicated in Taiwan because of the inferior outcomes for B-cell ALL with kinase fusions.
    URI: http://dx.doi.org/10.1038/s41598-021-85213-6
    https://www.webofscience.com/wos/woscc/full-record/WOS:000629623300076
    https://ir.csmu.edu.tw:8080/handle/310902500/23341
    關聯: SCIENTIFIC REPORTS ,2021,v11,issue 1
    显示于类别:[中山醫學大學研究成果] 期刊論文

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