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Title: | Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats |
Authors: | Tsai, HJ;Shih, CC;Chang, KY;Liao, MH;Liaw, WJ;Wu, CC;Tsao, CM |
Date: | 2021 |
Issue Date: | 2022-08-05T09:35:36Z (UTC)
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Publisher: | NATURE RESEARCH |
ISSN: | 2045-2322 |
Abstract: | Sepsis can lead to shock, multiple organ failure, and even death. Platelets play an active role in the pathogenesis of sepsis-induced multiple organ failure. Angiotensin (Ang)-(1-7), a biologically active peptide, counteracts various effects of Ang II and attenuates inflammatory responses, reactive oxygen species production, and apoptosis. We evaluated the effects of Ang-(1-7) on organ injury and platelet dysfunction in rats with endotoxaemia. We treated male Wistar rats with saline or lipopolysaccharide (LPS, 10 mg, intravenously) then Ang-(1-7) (1 mg/ kg, intravenous infusion for 3 h beginning 30 min after LPS administration). We analysed several haemodynamic, biochemical, and inflammatory parameters, as well as platelet counts and aggregation. Ang-(1-7) improved hypotension and organ dysfunction, and attenuated plasma interleukin-6, chemokines and nitric oxide production in rats after LPS administration. The LPS-induced reduction in platelet aggregation, but not the decreased platelet count, was restored after Ang-(1-7) treatment. The protein expression of iNOS and I kappa B, but not phosphorylated ERK1/2 and p38, was diminished in Ang-(1-7)-treated LPS rats. The histological changes in liver and lung were significantly attenuated in Ang-(1-7)-treated LPS rats. Our results suggest that Ang-(1-7) ameliorates endotoxaemic-induced organ injury and platelet dysfunction, likely through the inhibition of the inflammatory response and nitric oxide production. |
URI: | http://dx.doi.org/10.1038/s41598-020-79902-x https://www.webofscience.com/wos/woscc/full-record/WOS:000621919500073 https://ir.csmu.edu.tw:8080/handle/310902500/23333 |
Relation: | SCIENTIFIC REPORTS ,2021,v11,issue 1 |
Appears in Collections: | [中山醫學大學研究成果] 期刊論文
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