中山醫學大學機構典藏 CSMUIR:Item 310902500/23326
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23326


    题名: Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial-mesenchymal transition and inhibition of MMP-2
    作者: Chuang, YC;Hsieh, MC;Lin, CC;Lo, YS;Ho, HY;Hsieh, MJ;Lin, JT
    关键词: pinosylvin;nasopharyngeal cancer;matrix metalloproteinase;epithelial-mesenchymal transition;MAPK
    日期: 2021
    上传时间: 2022-08-05T09:35:27Z (UTC)
    出版者: SPANDIDOS PUBL LTD
    ISSN: 1021-335X
    摘要: Nasopharyngeal carcinoma (NPC) is a tumor located in the nasopharynx with highly invasive and metastatic properties. Metastasis is a primary cause of mortality in patients with NPC. The terpenoid polyphenol pinosylvin is a known functional compound of the Pinus species that exhibits anti-inflammatory effects; however, the effect of pinosylvin on human NPC cell migration and invasion is unclear. The present study aimed to investigate the functional role of pinosylvin in NPC cells (NPC-039, NPC-BM and RPMI 2650). Gap closure and Transwell assay indicated that pinosylvin at increasing concentrations inhibited migration and invasion of NPC-039 and NPC-BM cells. In addition to inhibiting the enzyme activity of MMP-2, pinosylvin also decreased the protein expression levels of MMP-2 and MMP-9. Pinosylvin decreased the expression of vimentin and N-cadherin and significantly increased the expression of zonula occludens-1 and E-cadherin in NPC cells. Additionally, pinosylvin suppressed the invasion and migration ability of NPC-039 and NPC-BM cells by mediating the p38, ERK1/2 and JNK1/2 pathways. The present results revealed that pinosylvin inhibited migration and invasion in NPC cells.
    URI: http://dx.doi.org/10.3892/or.2021.8094
    https://www.webofscience.com/wos/woscc/full-record/WOS:000656399200001
    https://ir.csmu.edu.tw:8080/handle/310902500/23326
    關聯: ONCOLOGY REPORTS ,2021,v46,issue 1
    显示于类别:[中山醫學大學研究成果] 期刊論文

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