中山醫學大學機構典藏 CSMUIR:Item 310902500/23309
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    题名: The minor C-allele of the rs2014355 variant in ACADS gene is associated with exercise-induced increase in HDL cholesterol levels in Taiwanese adults
    作者: Yang, TP;Shih, FF;Hsu, MY;Tsai, MH;Nfor, ON;Chen, PH;Ho, CC;Lin, CC;Liaw, YP
    关键词: ACADS gene;exercise;HDL-C;SNP
    日期: 2021
    上传时间: 2022-08-05T09:35:11Z (UTC)
    出版者: LIPPINCOTT WILLIAMS & WILKINS
    ISSN: 0025-7974
    摘要: We investigated the association between high-density lipoprotein cholesterol (HDL-C) and rs2014355 variant in the gene, short-chain acyl-coenzyme A dehydrogenase (ACADS) based on exercise habits. Data collected between 2008 and 2015 for individuals aged 30 to 70 years were available in the Taiwan Biobank (TWB) database. Backward stepwise linear regression was used to evaluate the associations of rs2014355 and exercise with HDL-C levels. We analyzed data of 5515 physically active and 4169 inactive biobank participants. The HDL-C concentrations were higher in the exercise compared to no exercise group (beta value, beta = 1.79856; P < .0001). We observed that the test for interaction was significant for the ACADS rs2014355 variant and exercise (P for interaction =.0412). Multivariate analyses showed significant association between TC+CC genotype and HDL-C in the exercise (beta = 1.09785; P value = .0146) compared to the no-exercise group (beta = -0.03754, P = .9154). In summary, the association between HDL-C and exercise differed significantly with respect to ACADS rs2014355 genotypes. Compared to the TT genotype, the TC+CC genotype together with exercise was associated with higher levels of HDL-C.
    URI: http://dx.doi.org/10.1097/MD.0000000000023838
    https://www.webofscience.com/wos/woscc/full-record/WOS:000612794500021
    https://ir.csmu.edu.tw:8080/handle/310902500/23309
    關聯: MEDICINE ,2021,v100,issue 1
    显示于类别:[中山醫學大學研究成果] 期刊論文

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