Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer

doi:10.1142/S0192415X21500105

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23288

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23288

Title:	Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer
Authors:	Hsieh, YS;Chu, SC;Huang, SC;Kao, SH;Lin, MS;Chen, PN
Keywords:	Gossypol;Metastasis;Invasion;Epithelial-Mesenchymal Transition;Cervical Cancer
Date:	2021
Issue Date:	2022-08-05T09:34:50Z (UTC)
Publisher:	WORLD SCIENTIFIC PUBL CO PTE LTD
ISSN:	0192-415X
Abstract:	Metastasis is the most prevalent cause of cancer-associated deaths amongst patients with cervical cancer. Epithelial-mesenchymal transition (EMT) is essential for carcinogenesis, and it confers metastatic properties to cancer cells. Gossypol is a natural polyphenolic compound with anti-inflammation, anti-oxidant, and anticancer activities. In this study, we investigated the antimetastatic and antitumour effects of gossypol on human cervical cancer cells (HeLa and SiHa cells). Gossypol exerted a strong inhibition effect on the migration and invasion of human cervical cancer cells. It reduced the focal adhesion kinase (FAK) pathway-mediated expression of matrix metalloproteinase-2 and urokinase-type plasminogen activator, subsequently inhibiting the invasion of SiHa cells. In addition, gossypol reversed EMT induced by transforming growth factor beta 1 (TGF-beta 1) and up-regulated epithelial markers, such as E-cadherin but significantly suppressed Ras homolog family member (Rho)A, RhoB, and p-Samd3. The tail vein injection model showed that gossypol treatment via oral gavage reduced lung metastasis. Gossypol also decreased tumour growth in vivo in the nude mouse xenograft model. All these findings suggest that gossypol suppressed the invasion and migration of human cervical cancer cells by targeting the FAK signaling pathway and reversing TGF-beta 1-induced EMT. Hence, gossypol warrants further attention for basic mechanistic studies and drug development.
URI:	http://dx.doi.org/10.1142/S0192415X21500105 https://www.webofscience.com/wos/woscc/full-record/WOS:000611545800010 https://ir.csmu.edu.tw:8080/handle/310902500/23288
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE ,2021,v49,issue 1, P181-198
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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