Association between endometriosis and risk of systemic lupus erythematosus

doi:10.1038/s41598-020-79954-z

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23286

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23286

Title:	Association between endometriosis and risk of systemic lupus erythematosus
Authors:	Fan, YH;Leong, PY;Chiou, JY;Wang, YH;Ku, MH;Wei, JCC
Date:	2021
Issue Date:	2022-08-05T09:34:48Z (UTC)
Publisher:	NATURE PORTFOLIO
ISSN:	2045-2322
Abstract:	To examine the association between endometriosis and the risk of systemic lupus erythematosus (SLE), this nationwide, population-based, retrospective cohort study was conducted based on National Health Insurance Research Database in Taiwan. Endometriosis (N=16,758) and non-endometriosis (N=16,758) groups were identified by matching baseline characteristics and comorbidities. Student's t-tests and the Kaplan-Meier estimator were utilized to estimate the hazard ratio (HR) and cumulative probability of SLE in the two groups. The endometriosis group showed a significantly higher incidence density rate (0.3 vs. 0.1 per 1000 person-years) and hazard ratio in SLE group (adjusted HR [aHR], 2.37; 95% confidence interval [CI] 1.35-4.14) compared to the non-endometriosis group. Subgroup analysis revealed that patients with endometriosis between 30 and 45 years of age, or were non-steroidal anti-inflammatory drug users, or were hormonal medications-free participants, had higher risks of SLE. For patients with endometriosis, surgical intervention did not significantly impact on the risk of SLE. Our results demonstrated an increased risk of SLE in patients with endometriosis. Clinicians should be aware of this association when managing patients with endometriosis or SLE.
URI:	http://dx.doi.org/10.1038/s41598-020-79954-z https://www.webofscience.com/wos/woscc/full-record/WOS:000621919100011 https://ir.csmu.edu.tw:8080/handle/310902500/23286
Relation:	SCIENTIFIC REPORTS ,2021,v11,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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