中山醫學大學機構典藏 CSMUIR:Item 310902500/23264
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    题名: Interactive association between dietary fat and sex on CDH13 cg02263260 methylation
    作者: Shiu, BH;Lu, WY;Tantoh, DM;Chou, MC;Nfor, ON;Huang, CC;Liaw, YP
    关键词: Epigenetics;DNA methylation;Cadherin;cg02263260;Sex;Fat intake
    日期: 2021
    上传时间: 2022-08-05T09:34:27Z (UTC)
    出版者: BMC
    摘要: BackgroundDNA methylation of Cadherin 13 (CDH13), a tumor suppressor gene is associated with gene repression and carcinogenesis. We determined the relation of dietary fat and sex with CDH13 cg02263260 methylation in Taiwanese adults.MethodsData of 870 eligible participants (430 men and 440 women) between 30 and 70 years were obtained from the Taiwan Biobank (TWB) database. The association of dietary fat and sex with CDH13 cg02263260 methylation was determined using multiple linear regression.ResultsThe association between sex and cg02263260 methylation was significant: beta-coefficient (beta)=0.00532; 95% confidence interval (CI)=0.00195-0.00868. Moreover, the interaction between sex and dietary fat on cg02263260 methylation was significant (P-value=0.0145). After stratification by sex, the association of dietary fat with cg02263260 methylation was significant only in women. Specifically, high dietary fat was positively associated with cg02263260 methylation in women (beta =0.00597; 95% CI=0.00061-0.01133) and the test for trend was significant (P-value=0.0283).ConclusionHigh fat intake was significantly associated with higher cg02263260 methylation in women and the test for trend was significant. These findings suggest that the association of fat intake and CDH13 cg02263260 might vary by sex and CDH13 cg02263260 methylation levels in women might increase as fat intake increases.
    URI: http://dx.doi.org/10.1186/s12920-020-00858-y
    https://www.webofscience.com/wos/woscc/full-record/WOS:000610102400011
    https://ir.csmu.edu.tw:8080/handle/310902500/23264
    關聯: BMC MEDICAL GENOMICS ,2021,v14,issue 1
    显示于类别:[中山醫學大學研究成果] 期刊論文

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