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https://ir.csmu.edu.tw:8080/ir/handle/310902500/22474
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| Title: | Features of indeterminate results of QuantiFERON-TB Gold In-Tube test in patients with haematological malignancies |
| Authors: | Huang, Chen-Cheng;Teng, Chieh-Lin Jerry;Wu, Ming-Feng;Lee, Ching-Hsiao;Chen, Hui-Chen;Huang, Wei-Chang |
| Keywords: | QuantiFERON-TB Gold in-Tube;haematological malignancy;indeterminate |
| Date: | 2021-07-02 |
| Issue Date: | 2022-06-28T02:40:59Z (UTC)
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| Publisher: | SAGE Publications Ltd |
| Abstract: | Background and aims:
The application of QuantiFERON-TB Gold in-Tube (QFT-GIT) in patients with haematological malignancies (HMs) has not been well studied. Therefore, we aimed to investigate the features of patients with HMs whose QFT-GIT results were indeterminate.
Methods:
This study enrolled patients with HMs for the analysis of QFT-GIT tests and additional 2-year follow-up. The characteristics and predictors of QFT-GIT indeterminate results were identified. Mycobacterium tuberculosis (TB) incidence rate (IR) and incidence rate ratio (IRR) were also investigated.
Results:
Of 89 participants, 27 (30.3%) had QFT-GIT indeterminate results. The QFT-GIT indeterminate patients were characterized with the diagnosis of leukaemia (63.0% versus 32.3%, p = 0.044), abnormal white blood count (WBC) (88.9% versus 14.5%, p = 0.001), abnormal lymphocyte percentage (81.5% versus 14.5%, p = 0.001) and lower lymphocyte count (×109/l) (0.5 versus 2.2, p = 0.000) when compared with those with determinate results. Meanwhile, abnormal WBC [odds ratios (OR): 15.18, p = 0.003] and lymphocyte percentage (OR: 6.90, p = 0.033) were predictors of indeterminate results. One patient with the QFT-GIT indeterminate status and high interferon-γ level of negative control result developed active TB with a TB IR of 18.5 per 1000 person-years and an IRR of 0.1 (95% confidence interval, 0.01–0.71) when compared with positive QFT-GIT patients without prophylaxis treatment.
Conclusion:
Abnormal ranges of WBC and lymphocyte differential count percentage were independent predictors useful to determine the optimal timing of implementing QFT-GIT test in patients with HMs. |
| URI: | https://ir.csmu.edu.tw:8080/handle/310902500/22474 |
| Relation: | Ther Adv Hematol, 12:20406207211028437 |
| Appears in Collections: | [醫學系] 期刊論文
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| 20406207211028437.pdf | | 409Kb | Adobe PDF | 144 | View/Open |
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