Impact of Glutathione and Vitamin B-6 in Cirrhosis Patients: A Randomized Controlled Trial and Follow-Up Study

doi:doi.org/10.3390/nu12071978

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/22456

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/22456

Title:	Impact of Glutathione and Vitamin B-6 in Cirrhosis Patients: A Randomized Controlled Trial and Follow-Up Study
Authors:	Lai, Chia-Yu Cheng, Shao-Bin Lee, Teng-Yu Hsiao, Yung-Fang Liu, Hsiao-Tien Huang, Yi-Chia
Contributors:	圖書館
Keywords:	Vitamin B-6;glutathione;oxidative stress;Child–Turcotte–Pugh score;liver cirrhosis
Date:	2020-07
Issue Date:	2022-06-27T03:22:36Z (UTC)
Publisher:	MDPI
Abstract:	Vitamin B-6 and glutathione (GSH) are antioxidant nutrients, and inadequate vitamin B-6 may indirectly limit glutathione synthesis and further affect the antioxidant capacities. Since liver cirrhosis is often associated with increased oxidative stress and decreased antioxidant capacities, we conducted a double-blind randomized controlled trial to assess the antioxidative effect of vitamin B-6, GSH, or vitamin B-6/GSH combined supplementation in cirrhotic patients. We followed patients after the end of supplementation to evaluate the association of vitamin B-6 and GSH with disease severity. In total, 61 liver cirrhosis patients were randomly assigned to placebo, vitamin B-6 (50 mg pyridoxine/d), GSH (500 mg/d), or B-6 + GSH groups for 12 weeks. After the end of supplementation, the condition of patient’s disease severity was followed until the end of the study. Neither vitamin B-6 nor GSH supplementation had significant effects on indicators of oxidative stress and antioxidant capacities. The median follow-up time was 984 d, and 21 patients were lost to follow-up. High levels of GSH, a high GSH/oxidized GSH ratio, and high GSH-St activity at baseline (Week 0) had a significant effect on low Child–Turcotte–Pugh scores at Week 0, the end of supplementation (Week 12), and the end of follow-up in all patients after adjusting for potential confounders. Although the decreased GSH and its related enzyme activity were associated with the severity of liver cirrhosis, vitamin B-6 and GSH supplementation had no significant effect on reducing oxidative stress and increasing antioxidant capacities.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/22456
Relation:	Nutrients ,12(7), PMC7399924
Appears in Collections:	[醫學系] 期刊論文

Files in This Item:

File	Description	Size	Format
nutrients-12-01978-v2.pdf		443Kb	Adobe PDF	74	View/Open

View Licence

Loading...