There are multiple histological types of soft-tissue sarcomas (STS) that are associated with different prognoses. Liposarcoma (LPS) is the most frequent subtype of STS in extremities and trunk wall in Taiwan.The myxoid liposarcoma is the second most common subtype of LPS and is associated with an intermediate-grade malignancy. STS and hematoma may be difficult to differentiate clinically. We report a case of a 35-year-old male presented with a mass lesion over the left thigh, which was initially misinterpreted as a hematoma on ultrasound. We also conducted a magnetic resonance imaging (MRI) study, which revealed the possible diagnosis of STS. After operation and histopathological examination, the diagnosis of myxoid liposarcoma was confirmed. We conducted a literature review of the clinical presentation, ultrasonic, and MRI findings to assess characteristics that will help the physician differentiate between hematomas and STS.
