中山醫學大學機構典藏 CSMUIR:Item 310902500/22396
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    請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/22396


    題名: Association between coarse particulate matter (PM 10-2.5) and nasopharyngeal carcinoma among Taiwanese men
    作者: Huang, Hsu-Chih;Tantoh, Disline Manli;Hsu, Shu-Yi;Nfor, Oswald Ndi;Frank, Cheau-Feng Lin;Lung, Chia-Chi;Ho, Chien-Chang;Chen, Chih-Yi;Liaw, Yung-Po
    關鍵詞: cancer;nasal cavity;neoplasms;respiratory tract diseases.
    日期: 2020-02
    上傳時間: 2022-06-07T03:12:29Z (UTC)
    出版者: BMJ
    摘要: The nasopharyngeal tract traps mainly coarse particles in inhaled air. Soluble carcinogenic compounds, endotoxins, and trace metals contained in these particles are potential causes of inflammation and oxidative stress which could enhance carcinogenesis. The aim of this study was to determine the association between coarse particulate matter (PM10-2.5) and nasopharyngeal cancer (NPC). A total of 521,098 men (355 cases and 520,743 non-cases), aged ≥40 years were included in this study. Data were retrieved from the Taiwan Cancer Registry, the Adult Preventive Medical Services Database, and the Air Quality Monitoring Database. PM10-2.5 was significantly associated with a higher risk of NPC after adjusting for SO2, NOx, O3, age, body mass index, smoking, alcohol drinking, betel nut chewing, exercise, hypertension, diabetes, and hyperlipidemia. With PM10-2.5<20.44 μg/m3 as the reference, the ORs and 95% CIs were 1.47; 1.03-2.11, 1.34; 0.94-1.91, and 1.68; 1.16-2.44 for 20.44≤PM10-2.5<24.08, 24.08≤PM10-2.5<29.27, and PM10-2.5≥29.27 μg/m3, respectively. PM10-2.5 remained significantly associated with a higher risk of NPC after further adjustments were made for the aforementioned covariates and PM2.5 The ORs; 95% CIs were 1.42; 0.96 to 2.12, 1.41; 0.94 to 2.10, and 1.71; 1.10 to 2.66 for 20.44≤PM10-2.5<24.08, 24.08≤PM10-2.5<29.27, and PM10-2.5≥29.27 μg/m3, respectively. In conclusion, PM10-2.5 was significantly associated with a higher risk of NPC in Taiwanese men.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/22396
    關聯: J Investig Med, 68(2),419-424.
    顯示於類別:[醫學系] 期刊論文

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