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Title: | Protective effect of nerolidol on lipopolysaccharide-induced acute lung injury through the inhibition of NF-κB activation by the reduction of p38 MAPK and JNK phosphorylation |
Authors: | Chen, Shih-Pin;Su, Chun-Hung;Rosa, Huang-Liu;Lee, Min-Wei;Chian, Chen-Yu;Chen, Wen-Ying;Chen, Chun-Jung;Wu, Sheng-Wen;Kuan, Yu-Hsiang |
Keywords: | Nerolidol;LPSA;cute lung injury;NF-κB;p38 MAPK;JNK |
Date: | 2020-06 |
Issue Date: | 2022-06-06T02:33:56Z (UTC)
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Publisher: | Elsevier Inc. |
Abstract: | Acute lung injury (ALI) is a severe syndrome, and there are no effective therapeutic appropriate medicines. Nerolidol, which exists in the essential oils of aromatic plants and flowers, exhibits antioxidative and anti-inflammatory activities. The present study evaluated the potential protective effect of nerolidol in ALI and the related mechanism in lipopolysaccharide (LPS)-treated mice. Here, nerolidol inhibited the LPS-induced neutrophil and other leukocyte infiltration of the alveolar space. LPS increased cytokines, chemokines, and adhesion molecules, and proinflammatory protein production was inhibited by nerolidol. LPS-induced phosphorylation of NF-κB p65, p38 MAPK, JNK, ERK were inhibited by nerolidol. The inhibitory concentration of nerolidol for the phosphorylation of NF-κB p65 and its upstream factors, p38 MAPK and JNK, was similar to the inflammatory responses of ALI. In conclusion, nerolidol is a potential protective agent in ALI via the inhibition of NF-κB activation and its upstream factors phosphorylation of p38 MAPK and JNK. |
URI: | https://ir.csmu.edu.tw:8080/handle/310902500/22379 |
Relation: | Journal of Functional Foods, Volume 69, 103943 |
Appears in Collections: | [醫學系] 期刊論文
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