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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/22377
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| Title: | Cholecystectomy reduces subsequent cholangiocarcinoma risk in choledocholithiasis patients undergoing endoscopic intervention |
| Authors: | Wang, Chi-Chih;Tseng, Ming-Hseng;Wu, Sheng-Wen;Yang, Tzu-Wei;Chen, Hsuan-Yi;Sung, Wen-Wei;Su, Chang-Cheng;Wang, Yao-Tung;Lin, Chun-Che;Tsai, Ming-Chang |
| Keywords: | Cholangiocarcinoma;Cholecystectomy;Endoscopic papillary balloon dilatation;Endoscopic sphincterotomy;Recurrent biliary events. |
| Date: | 2020-12-15 |
| Issue Date: | 2022-06-06T02:23:23Z (UTC)
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| Publisher: | Baishideng Publishing Group Inc. |
| Abstract: | Background: Cholangiocarcinoma is a disease with a high mortality rate. Our previous study revealed that cholelithiasis patients who undergo endoscopic sphincterotomy (ES)/endoscopic papillary balloon dilatation are at a higher risk for subsequent cholangiocarcinoma than cholelithiasis patients who undergo cholecystectomy.
Aim: To clarify the relationship between recurrent biliary events and subsequent cholangiocarcinoma risk in choledocholithiasis patients.
Methods: From one million random cases in the Taiwan National Health Insurance Research Database 2004-2011, we selected symptomatic choledocholithiasis patients older than 18 years who were admitted from January 2005 to December 2009 (study group). Cases for a control group were defined as individuals who had never been diagnosed with cholelithiasis, matched by sex and age in a 1:3 ratio. The study group was further divided into ES/endoscopic papillary balloon dilatation, both ES/endoscopic papillary balloon dilatation and cholecystectomy, and no intervention groups.
Results: We included 2096 choledocholithiasis patients without previous intervention or cholangiocarcinoma. A total of 12 (2.35%), 11 (0.74%), and 1 (1.00%) subsequent cholangiocarcinoma cases were diagnosed among 511 ES/endoscopic papillary balloon dilatation patients, 1485 patients with no intervention, and 100 ES/endoscopic papillary balloon dilatation and cholecystectomy patients, respectively. The incidence rates of recurrent biliary event were 527.79/1000 person-years and 286.69/1000 person-years in the subsequent cholangiocarcinoma and no cholangiocarcinoma group, showing a high correlation between subsequent cholangiocarcinoma risk and recurrent biliary events.
Conclusion: Choledocholithiasis patients who undergo further cholecystectomy after ES/endoscopic papillary balloon dilatation have decreased subsequent cholangiocarcinoma risk due to reduced recurrent biliary events. |
| URI: | https://ir.csmu.edu.tw:8080/handle/310902500/22377 |
| Relation: | World J Gastrointest Oncol, 12(12), 1381-1393 |
| Appears in Collections: | [醫學系] 期刊論文
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