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    Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/22374


    Title: 1-Nitropyrene Induced Reactive Oxygen Species-Mediated Apoptosis in Macrophages through AIF Nuclear Translocation and AMPK/Nrf-2/HO-1 Pathway Activation
    Authors: Su, Chun-Hung;Ho, Yung-Chuan;Lee, Min-Wei;Tseng, Ching-Chi;Lee, Shiuan-Shinn;Hsieh, Ming Kun;Chen, Hsin-Hung;Lee, Chien-Ying;Wu, Sheng-Wen;Kuan, Yu-Hsiang
    Date: 2021-07-13
    Issue Date: 2022-06-06T02:07:12Z (UTC)
    Publisher: HINDAWI
    Abstract: 1-Nitropyrene (1-NP), one of the most abundant nitropolycyclic aromatic hydrocarbons (nitro-PAHs), is generated from the incomplete combustion of carbonaceous organic compounds. 1-NP is a specific marker of diesel exhaust and is an environmental pollutant and a probable carcinogen. Macrophages participate in immune defense against the invasive pathogens in heart, lung, and kidney infection diseases. However, no evidence has indicated that 1-NP induces apoptosis in macrophages. In the present study, 1-NP was found to induce concentration-dependent changes in various cellular functions of RAW264.7 macrophages including cell viability reduction; apoptosis generation; mitochondrial dysfunction; apoptosis-inducing factor (AIF) nuclear translocation; intracellular ROS generation; activation of the AMPK/Nrf-2/HO-1 pathway; changes in the expression of BCL-2 family proteins; and depletion of antioxidative enzymes (AOE), such as glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) These results indicate that 1-NP induced apoptosis in macrophages through AIF nuclear translocation and ROS generation due to mitochondrial dysfunction and to the depletion of AOE from the activation of the AMPK/Nrf-2/HO-1 pathway.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/22374
    Relation: Oxid Med Cell Longev , 2021, 9314342
    Appears in Collections:[醫學系] 期刊論文

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