Berberine-targeted miR-21 chemosensitizes oral carcinomas stem cells

doi:doi.org/10.18632/oncotarget.20723

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/22360

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题名:	Berberine-targeted miR-21 chemosensitizes oral carcinomas stem cells
作者:	Lin, Che-Yi;Hsieh, Pei-Ling;Liao, Yi-Wen;Peng, Chih-Yu;Lu, Ming-Yi;Yang, Ching-Hsuan;Yu, Cheng-Chia;Liu, Chia-Ming
关键词:	berberine;miR-21;oral squamous cell carcinomas
日期:	2017-09-08
上传时间:	2022-05-30T03:39:43Z (UTC)
摘要:	Cancer recurrence and chemoresistance are two major obstacles to the treatment of oral squamous cell carcinomas (OSCC). And cancer stem cells (CSCs) have been found to possess tumor initiating, self-renewal and metastasis abilities, resulting in the relapse and chemoresistance of OSCC. In the present study, we investigated the anti-CSCs effect of berberine, a phenanthrene alkaloid isolated from the Berberis genus. Our results demonstrated that berberine dose dependently downregulated the oncogenicity in vitro, including ALDH1 activity, self-renewal property, and colony formation and invasion abilities as well as potentiated chemosensitivity of OSCC-CSCs. In addition, tumor growth in mice was attenuated after oral gavage treatment of berberine. We showed that the expression of miR-21 was suppressed following administration of berberine in OSCC-CSCs. And inhibition of endogenous miR-21 reduced the characteristics of CSCs, including self-renewal, migration, invasion capabilities and ALDH1 activity. Taken together, we demonstrated the anti-CSC effect of berberine in oral cancer and its potential to serve as adjuvant to traditional chemotherapy to improve treatment effect.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/22360
關聯:	Oncotarget, 8(46), 80900-80908
显示于类别:	[口腔醫學研究所] 期刊論文

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