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    Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/22360


    Title: Berberine-targeted miR-21 chemosensitizes oral carcinomas stem cells
    Authors: Lin, Che-Yi;Hsieh, Pei-Ling;Liao, Yi-Wen;Peng, Chih-Yu;Lu, Ming-Yi;Yang, Ching-Hsuan;Yu, Cheng-Chia;Liu, Chia-Ming
    Keywords: berberine;miR-21;oral squamous cell carcinomas
    Date: 2017-09-08
    Issue Date: 2022-05-30T03:39:43Z (UTC)
    Abstract: Cancer recurrence and chemoresistance are two major obstacles to the treatment of oral squamous cell carcinomas (OSCC). And cancer stem cells (CSCs) have been found to possess tumor initiating, self-renewal and metastasis abilities, resulting in the relapse and chemoresistance of OSCC. In the present study, we investigated the anti-CSCs effect of berberine, a phenanthrene alkaloid isolated from the Berberis genus. Our results demonstrated that berberine dose dependently downregulated the oncogenicity in vitro, including ALDH1 activity, self-renewal property, and colony formation and invasion abilities as well as potentiated chemosensitivity of OSCC-CSCs. In addition, tumor growth in mice was attenuated after oral gavage treatment of berberine. We showed that the expression of miR-21 was suppressed following administration of berberine in OSCC-CSCs. And inhibition of endogenous miR-21 reduced the characteristics of CSCs, including self-renewal, migration, invasion capabilities and ALDH1 activity. Taken together, we demonstrated the anti-CSC effect of berberine in oral cancer and its potential to serve as adjuvant to traditional chemotherapy to improve treatment effect.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/22360
    Relation: Oncotarget, 8(46), 80900-80908
    Appears in Collections:[口腔醫學研究所] 期刊論文

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