中山醫學大學機構典藏 CSMUIR:Item 310902500/22325
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    题名: Maintenance interferon therapy in chronic hepatitis C patients who failed initial antiviral therapy: A meta-analysis
    作者: Hung-Chang Hung;Hsien-Hua Liao;Shiuan-Chih Chen;Shih-Ming Tsao;Yuan-Ti Lee
    贡献者: 中山醫學大學;醫研所
    日期: 2019-05
    上传时间: 2022-05-12T03:18:43Z (UTC)
    出版者: Spandidos Publications
    摘要: Objectives:
    To evaluate the effect of pegylated interferon maintenance therapy in patients with chronic hepatitis C who failed initial antiviral therapy.

    Methods:
    This is a meta-analysis of 6 randomized controlled trials that met the eligibility criteria. In all, 2438 chronic hepatitis C patients who failed to achieve sustained virologic response after initial treatment with pegylated interferon and ribavirin (antiviral therapy nonresponders or relapsers) were enrolled; 1237 patients received maintenance therapy (Maintenance group) and 1201 received no treatment (Observation group).

    Results:
    The pooled analyses found that patients in the Maintenance group had a significantly higher rate of normal alanine aminotransferase than did patients in the Observation group (pooled odds ratio [OR] 4.436, 95% confidence interval [CI] 1.225–16.064, P = .023), but there was no significant difference between the 2 groups in the incidence of hepatocellular carcinoma (pooled OR 0.872, 95% CI 0.501–1.519, P = .630), or the mortality rate (pooled OR 1.564, 95% CI 0.807–3.032, P = .185).

    Conclusions:
    Interferon-based maintenance therapy in patients with chronic hepatitis C who failed initial antiviral therapy improved liver inflammation as indicated by blood chemistry (alanine aminotransferase).
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/22325
    關聯: Medicine (Baltimore),98(19),e15563.
    显示于类别:[醫學研究所] 期刊論文

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