中山醫學大學機構典藏 CSMUIR:Item 310902500/21860
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    题名: Impacts of early insulin treatment vs glimepiride in diabetic patients with background metformin therapy A nationwide retrospective cohort study
    作者: Yen Fu-Shun;Hsu Chih-Cheng;Su Yuan-Chih;Wei James Cheng-Chung;Hwu Chii-Min
    贡献者: 中山醫學大學;醫研所
    关键词: propensity score;mortality;cause of death
    日期: 2021-03-05
    上传时间: 2021-10-26T08:09:27Z (UTC)
    出版者: Wolters Kluwer Health, Inc.
    摘要: Type 2 diabetes mellitus (T2DM) is a progressive disease. After metformin failure, the addition of insulin or sulfonylureas might increase the risk of hypoglycemia and cardiovascular (CV) morbidity. Here, the risk of all-cause mortality was compared between early insulin treatment and glimepiride use in T2DM patients with background metformin therapy.

    We conducted a 9-year retrospective cohort study from the population-based National Health Insurance Research Database in Taiwan. A total of 2054 patients with T2DM under insulin or glimepiride treatment were enrolled during 2004 to 2012. Overall event rates of all-cause mortality were compared between 1027 insulin users and 1027 matched glimepiride users.

    After the propensity score matching, the mortality rates were 72.5 and 4.42 per 1000 person-years for insulin users and glimepiride users. The adjusted hazard ratio of mortality was 14.47 (95% CI: 8.64–24.24; P value <.001) as insulin compared with glimepiride users. The insulin users had significantly higher risk of CV death (adjusted hazard ratio 7.95, 95% CI 1.65–38.3, P = .01) and noncardiovascular death (adjusted hazard ratio 14.9, 95% CI 8.4–26.3, P < .001).

    The nationwide study demonstrated that metformin plus insulin therapy was associated with higher risk of all-cause mortality.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/21860
    關聯: Medicine, Volume 100, Issue 9, p e25085
    显示于类别:[醫學研究所] 期刊論文

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