中山醫學大學機構典藏 CSMUIR:Item 310902500/21854
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    题名: Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome
    作者: Chun-Chieh Chen;Yu-Hsiang Wei;Chia-Chen Huang;Shin-Hui Hung;Zeng-Wei Wang;Ruey-Hong Wong
    贡献者: 中山醫學大學;醫研所
    关键词: FASTING PLASMA-GLUCOSE;GENE POLYMORPHISM;ASSOCIATION;POPULATION;RISK;CRITERION;HBA1C
    日期: 2021-05-03
    上传时间: 2021-10-26T07:44:30Z (UTC)
    出版者: HINDAWI
    摘要: Backgrounds. Adiponectin (apM1) may affect insulin sensitivity, and tumor necrosis factor (TNF-alpha) can inhibit the binding of insulin and insulin receptors. However, whether apM1 and TNF-alpha genes influence the development of metabolic syndrome (MetS) preceded by insulin resistance is unclear. The current study examines the interactions between the apM1 +45 genotypes, TNF-alpha -308 genotypes, and insulin resistance on the occurrence of MetS. Methods. A total of 329 community residents were recruited, and their personal characteristics were collected. Waist circumference and biochemical markers were examined for determining MetS. Genotypes were identified by the polymerase chain reaction. Results. After adjusting for the confounding effects, compared to apM1 +45 GG and GT genotypes carriers with HOMR-IR less than 2.0, those carriers with HOMA-IR greater than 2.0 had an increased MetS risk (OR=4.35, 95% CI 2.14-8.85). Further, apM1 +45 TT carriers with HOMA-IR greater than 2.0 experienced a higher MetS risk (OR=5.91, 95% CI 2.78-12.54). A significant interaction of the apM1 +45 genotype and insulin resistance on the MetS development was observed (P=0.04). Conclusion. Our data suggested that apM1 +45 genotypes might modify the effect of insulin resistance on the development of Taiwanese MetS.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/21854
    關聯: BioMed Research International , Volume 2021, Article ID 5570827
    显示于类别:[醫學研究所] 期刊論文

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