Electrosprayed calcium silicate nanoparticle-coated titanium implant with improved antibacterial activity and osteogenesis

doi:doi.org/10.1016/j.colsurfb.2021.111699

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/21845

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題名:	Electrosprayed calcium silicate nanoparticle-coated titanium implant with improved antibacterial activity and osteogenesis
作者:	Csaba, Buga Chen, Chun-Cheng Matyas, Hunyadi Attila, Csik Csaba, Hegedus Ding, Shinn-Jyh
貢獻者:	中山醫學大學;牙醫系
關鍵詞:	Calcium silicate;Electrospray deposition;Bonding strength;Bioactive coating;Antibacterial coating
日期:	2021-06
上傳時間:	2021-10-18T02:45:54Z (UTC)
出版者:	Elsevier Inc.
摘要:	To ensure clinical success, the implant and the surrounding bone tissue must not only be integrated, but also must not be suspected of infection. In this work, an antibacterial and bioactive nanostructured calcium silicate (CaSi) layer on titanium substrate by an electrospray deposition method was prepared, followed by annealing at 700, 750 and 800 °C to improve the bonding strength of the CaSi coating. The phase composition, microstructure and bonding strength of the CaSi coatings were examined. Human mesenchymal stem cells (hMSCs), Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) species were used to analyze the osteogenic and antibacterial activity of the coatings, respectively. Experimental results showed that the as-prepared CaSi coating was mainly composted of β-dicalcium silicate phase with a particle size of about 300 nm. After annealing, the thickness of the oxidation reaction layer increased obviously from 0.3 μm to 1 μm with increase in temperature, which was confirmed by the cross-sectional morphology and element depth profile. The bonding strength of the coating annealed at 750 °C (19.0 MPa) was significantly higher (p < 0.05) than that of the as-prepared coating (4.4 MPa) and the ISO 13,779 standard (15 MPa). The results of antibacterial efficacy and stem cell osteogenesis consistently elaborated that the 750 °C-annealed coating had higher activity than the as-prepared coating and the Ti control. It is concluded that after annealing at 750 °C, the CaSi nanoparticle-coated Ti implant had good bond strength, osteogenic and antibacterial activity.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/21845
關聯:	COLLOIDS AND SURFACES B-BIOINTERFACES,Volume 202, June 2021, 111699
顯示於類別:	[口腔醫學研究所] 期刊論文

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