Preparation and characterization of gellan gum film as a carrier of 5-Chloro-8-hydroxy-7-iodoquinoline (CQ) for oral cancer therapy

中山醫學大學機構典藏 CSMUIR > 行政單位 > 研發處 > 期刊論文 > Item 310902500/21831

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题名:	Preparation and characterization of gellan gum film as a carrier of 5-Chloro-8-hydroxy-7-iodoquinoline (CQ) for oral cancer therapy
作者:	Yi-Nuan Wong ； Ming-Wei Lee
贡献者:	中山醫學大學
关键词:	Gellan gum ； 5-Chloro-8-hydroxy-7-iodoquinoline ； oral cancer treatment patch
日期:	2018-06-01
上传时间:	2021-10-04T03:26:03Z (UTC)
出版者:	研發處育成中心暨產學合作組
摘要:	In this study, gellan gum (GG) film was prepared with chemotherapy drug 5-Chloro-8-hydroxy-7- iodoquinoline (CQ) as an oral cancer treatment patch. Covalent conjugation of CQ and GG was via I-Ethyl-3-(3-dimethylamino-propyl) carbodiimide (EDC)-mediation (GG/CQ/EDC film). The thickness of GG / CQ / EDC film was 22 ± 4 μm with 87.7 % gel content and 96.1 % water content. Mechanical testing revealed maximum tensile strength and elongation percentage at break of 1.98 kgf/mm^2 and 4.24 %, respectively. Drug release experiment lasted for 45 days, and the amount of CQ released was 82.4 %. Huguchi model fit the GG / CQ / EDC release data with high correlation coefficient (R^2=09990). From the results of animal testing, GG/CQ/EDC film can decrease epidermal growth factor receptor (EGFR) expression and suppress tumor progression. These findings provide insight into the potential use of GG/CQ/EDC film for oral cancer therapy in clinical practice.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/21831
關聯:	中山醫學雜誌, 29卷1期, P17 - 25
显示于类别:	[研發處] 期刊論文

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