中山醫學大學機構典藏 CSMUIR:Item 310902500/21803
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17901/22917 (78%)
造访人次 : 7640828      在线人数 : 271
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21803


    题名: Involvement of extracellular transglutaminase 2 in migration of lung cancer cells
    作者: Lee, Wen-Jun Wu ； Yu-Lin Chao ； Wuan-Chun Chen ； Jia-Yu Kuo ； Yi-Ju
    贡献者: 中山醫學大學
    关键词: transglutaminase 2 ； lung cancer ； migration
    日期: 2019-12-01
    上传时间: 2021-09-13T03:55:41Z (UTC)
    出版者: 研發處育成中心暨產學合作組
    摘要: Transglutaminase 2 (TG2) is a highly complex protein with enzymatic and non-enzymatic functions. It is localized in multiple cellular compartments, inside and outside the cell. Overexpression of TG2 has been implicated in cancer development. However, relatively little attention has been paid to the effects of extracellular TG2. Here, we examined the involvement of extracellular TG2 in cell migration using a lung cancer cell line CL1-0 and its invasive subline CL1-5. Our results showed that CL1-5 exhibits higher levels of TG2 in cell lysates and conditioned medium, when compared with CL1-0. Exogenous application of recombinant TG2 protein to CL1-0 cells substantially augmented migration. Inclusion of TG2 antibody to block extracellular TG2 hampered migration of CL1-5 cells. The stimulatory effect of extracellular TG2 on cell migration was independent of its transamidase activity, as treatment of cells with the TG2 inhibitor Z-DON did not suppress migration. Further examination of the regulatory mechanisms for TG2 expression revealed that the DNA demethylating agent 5-Aza-2'-deoxycystidine increases levels of TG2, but the histone deacetylase inhibitor trichostatin A exerts no effect on CL1- 0 cells. Collectively, our results demonstrated the significance of extracellular TG2 in promoting migration of lung cancer cells. Blockade of extracellular TG2 could be a potential strategy for cancer therapy.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/21803
    關聯: 中山醫學雜誌, 30卷2期, P85 - 91
    显示于类别:[研發處] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    Involvement of extracellular transglutaminase 2 in migration of lung cancer cells.pdf471KbAdobe PDF135检视/开启


    检视Licence

    SFX Query

    在CSMUIR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈