Reactive angioendotheliomatosis (RAE) is a rare disease characterized by angioproliferation limited to skin. Patients with coexistent systemic diseases are most vulnerable. Histopathologically, it is marked by hyperplasia of endothelial cells with vascular proliferation but without cytological atypia. Although the pathogenesis is still not completely understood, it has been proposed that immunologic factors and hypoxic stimulus lead to RAE. In what is the first reported case in Taiwan, we describe a 76-year-old female with a history of coronary artery disease who developed RAE after perforated peptic ulcer surgery.
