Molecular characteristics of KRAS, BRAF, and PIK3CA mutation frequency in sessile serrated adenomas and polyps in patients from central Taiwan

中山醫學大學機構典藏 CSMUIR > 行政單位 > 研發處 > 期刊論文 > Item 310902500/21771

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21771

题名:	Molecular characteristics of KRAS, BRAF, and PIK3CA mutation frequency in sessile serrated adenomas and polyps in patients from central Taiwan
作者:	Tsai, Ching-Pin Lin ； Hung-Hsiu Liao ； Xiao-Fan Huang ； Jeng-Dong Hsu ； Ho-Li Wang ； Nu-Man
贡献者:	中山醫學大學
关键词:	Interval cancer ； Sessile serrated adenomas (SSAs) ； KRAS ； BRAF ； PIK3CA
日期:	2021-06-01
上传时间:	2021-09-13T02:53:02Z (UTC)
出版者:	研發處育成中心暨產學合作組
摘要:	Background: Colorectal cancer (CRC) is one of t he most common cancers, and patients with CRC usually present with several polyps that can be detected by colonoscopy, which is a commonly used screening tool. Sessile serrated adenomas (SSAs) were a polyp type considered to have a high risk of becoming interval colorectal cancer following negative colonoscopy. Aim: The purpose of this study was to evaluate the molecular features of SSAs in central Taiwan. Methods and Results: We used the FemtoPath primer kit to detect BRAF, KRAS, and PIK3CA mutations for 32 specimens: BRAF (V600E), KRAS (G12D, G12C, and G13D), and PIK3CA (H1047Y) mutations were detected. Conclusion: Almost all SSA samples contained BRAF mutations, and KRAS gene mutations were detected to a statistical significance for patients with high dysplasia and for those with more than three polyps.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/21771
關聯:	中山醫學雜誌 , 32卷1期, P31 - 37
显示于类别:	[研發處] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
Molecular characteristics of KRAS, BRAF, and PIK3CA mutation frequency in sessile serrated adenomas .pdf		1092Kb	Adobe PDF	177	检视/开启

检视Licence

在CSMUIR中所有的数据项都受到原著作权保护.

TAIR相关文章