Association of LINC00673 Genetic Variants with Progression of Oral Cancer

doi:doi.org/10.3390/jpm11060468

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學研究所 > 期刊論文 > Item 310902500/21758

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21758

Title:	Association of LINC00673 Genetic Variants with Progression of Oral Cancer
Authors:	Su, Shih-Chi Lin, Chiao-Wen Ju, Po-Chung Chang, Lun-Ching Chuang, Chun-Yi Liu, Yu-Fan Hsieh, Ming-Ju Yang, Shun-Fa
Contributors:	中山醫學大學;醫研所
Keywords:	oral squamous cell carcinoma;long noncoding RNA;single-nucleotide polymorphism;lymph node metastasis;NONCODING RNA LINC00673;SUSCEPTIBILITY;HEAD;PROLIFERATION;EPIDEMIOLOGY;POLYMORPHISM;ABERRATIONS;MELANOMA;INVASION;LSD1
Date:	2021-05-25
Issue Date:	2021-09-06T03:49:00Z (UTC)
Publisher:	MDPI
Abstract:	Oral squamous cell carcinoma (OSCC) is a multifactorial malignancy, and its high incidence and mortality rate remain a global public health burden. Polymorphisms in the long intergenic noncoding RNA 673 (LINC00673) have been currently connected to the predisposition to various cancer types. The present study attempted to explore the impact of LINC00673 gene polymorphisms on the risk and progression of OSCC. Three LINC00673 single-nucleotide polymorphisms (SNPs), including rs11655237, rs9914618, and rs6501551, were evaluated in 1231 OSCCC cases and 1194 cancer-free controls. We did not observe any significant association of three individual SNPs with the risk of OSCC between the case and control group. However, while assessing the clinicopathological parameters, patients carrying at least one minor allele of rs9914618 (GA and AA; OR, 1.286; 95% CI, 1.008-1.642; p = 0.043) were found to develop lymph node metastasis more often compared to those who are homozygous for the major allele. Further stratification analyses revealed that this genetic correlation with increased risk of lymphatic spread was further fortified in habitual betel quid chewers (OR, 1.534; 95% CI, 1.160-2.028; p = 0.003) or smokers (OR, 1.320; 95% CI, 1.013-1.721; p = 0.040). Moreover, through analyzing the dataset from The Cancer Genome Atlas (TCGA), we found that elevated LINC00673 levels were associated with the development of large tumors in patients with head and neck squamous cell carcinoma and the risk of lymphatic spread in smokers. These data demonstrate a joint effect of LINC00673 rs9914618 with betel nut chewing or smoking on the progression of oral cancer.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/21758
Relation:	JOURNAL OF PERSONALIZED MEDICINE, Volume 11, Issue 6, 468
Appears in Collections:	[醫學研究所] 期刊論文

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