Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial

doi:doi.org/10.1017/S0007114518001241

中山醫學大學機構典藏 CSMUIR > 健康管理學院 > 營養學系暨碩士班 > 期刊論文 > Item 310902500/21746

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21746

Title:	Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial
Authors:	Chi-Hua Yen;Ying-Ju Chu;Bor-Jen Lee;Yi-Chin Lin;Ping-Ting Lin
Keywords:	CAT catalase;GPx glutathione peroxidase;HOMA-IR homoeostatic model assessment of insulin resistance;HbA1c glyco Hb;MES medication effect scores;SOD superoxide dismutase;Antioxidants;Glucose;Liquids;Type 2 diabetes;Ubiquinol.
Date:	2018-07
Issue Date:	2021-09-06T01:55:45Z (UTC)
Publisher:	Cambridge University Press
Abstract:	Ubiquinone is a lipid antioxidant, and a novel liquid ubiquinol (a hydro-soluble, reduced form of coenzyme Q10) supplement was recently developed. The purpose of this study was to examine the levels of glucose, lipids and antioxidant capacity of type 2 diabetes patients after liquid ubiquinol supplementation. This study was designed as a randomised, double-blind, placebo-controlled trial. In all, fifty participants were randomly assigned to a placebo (n 25) or liquid ubiquinol (100 mg/d, n 25) group, and the intervention lasted for 12 weeks. Plasma coenzyme Q10, glucose homoeostasis parameters, lipid profiles, oxidative stress and antioxidative enzyme activities were measured during the study. After 12 weeks of supplementation, glyco Hb (HbA1c) value was significantly decreased in the liquid ubiquinol group (P=0·03), and subjects in the liquid ubiquinol group had significantly lower anti-glycaemic medication effect scores (MES) compared with those in the placebo group (P=0·03). The catalase (P<0·01) and glutathione peroxidase (P=0·03) activities were increased significantly after supplementation. Plasma coenzyme Q10 was correlated with the insulin level (P=0·05), homoeostatic model assessment-insulin resistance (P=0·07), quantitative insulin sensitivity check index (P=0·03) and the anti-hyperglycaemic agents' MES (P=0·03) after supplementation. Lipid profiles did not change after supplementation; however, the subjects in the placebo group had a significantly lower level of HDL-cholesterol after 12 weeks of intervention. In conclusion, oral intake of 100 mg/d liquid ubiquinol might benefit type 2 diabetes patients by increasing antioxidant enzyme activity levels, reducing HbA1c levels and maintaining HDL-cholesterol levels.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/21746
Relation:	Br J Nutr, 120(1), p.57-63.
Appears in Collections:	[營養學系暨碩士班] 期刊論文

Files in This Item:

File	Description	Size	Format
effect-of-liquid-ubiquinol-supplementation-on-glucose-lipids-and-antioxidant-capacity-in-type-2-diabetes-patients-a-double-blind-randomised-placebo-controlled-trial.pdf		1181Kb	Adobe PDF	483	View/Open

View Licence

Loading...