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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/21743
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| Title: | Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial |
| Authors: | Chien-Chang Ho;Po-Sheng Chang;Hung-Wun Chen;Po-Fu Lee;Yun-Chi Chang;Ching-Yu Tseng;Ping-Ting Lin |
| Keywords: | ubiquinone supplementation, athletes, glycaemia, antioxidant, sport nutrition |
| Date: | 2020-09-03 |
| Issue Date: | 2021-09-06T01:42:32Z (UTC)
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| Publisher: | MDPI |
| Abstract: | The aim of this study is to investigate the glycemic profile, oxidative stress, and antioxidant capacity in athletes after 12 weeks of ubiquinone supplementation. It was a double-blinded, randomized, parallel, placebo-controlled study. Thirty-one well-trained college athletes were randomly assigned to ubiquinone (300 mg/d, n = 17) or placebo group (n = 14). The glycemic profile [fasting glucose, glycated hemoglobin (HbA1c), homeostatic model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI)], plasma and erythrocyte malondialdehyde (MDA), total antioxidant capacity (TAC), and ubiquinone status were measured. After supplementation, the plasma ubiquinone concentration was significantly increased (p < 0.05) and the level of erythrocyte MDA was significantly lower in the ubiquinone group than in the placebo group (p < 0.01). There was a significant correlation between white blood cell (WBC) ubiquinone and glycemic parameters [HbA1c, r = −0.46, p < 0.05; HOMA-IR, r = −0.67, p < 0.01; QUICKI, r = 0.67, p < 0.01]. In addition, athletes with higher WBC ubiquinone level (≥0.5 nmol/g) showed higher erythrocyte TAC and QUICKI and lower HOMA-IR. In conclusion, we demonstrated that athletes may show a better antioxidant capacity with higher ubiquinone status after 12 weeks of supplementation, which may further improve glycemic control. |
| URI: | https://ir.csmu.edu.tw:8080/handle/310902500/21743 |
| Relation: | Antioxidants (Basel), 9(9), 823. |
| Appears in Collections: | [營養學系暨碩士班] 期刊論文
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| antioxidants-09-00823.pdf | | 1304Kb | Adobe PDF | 231 | View/Open |
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