中山醫學大學機構典藏 CSMUIR:Item 310902500/21657
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    题名: Validation of EGFL6 expression as a prognostic marker in patients with lung adenocarcinoma in Taiwan: a retrospective study
    作者: Chun-Chi Chang;Wen-Wei Sung;Hui-Ting Hsu;Chung-Min Yeh;Chien-Hsun Lee;Ya-Ling Chen;Ta-Chih Liu;Kun-Tu Yeh
    日期: 2018-06-22
    上传时间: 2021-08-19T03:04:57Z (UTC)
    出版者: BMJ
    摘要: Objective Lung adenocarcinoma is a non-small cell lung cancer, a common cancer in both genders, and has poor clinical outcome. Our aim was to evaluate the role of epidermal growth factor (EGF)-like domain multiple 6 (EGFL6) and its prognostic significance in lung adenocarcinoma.

    Methods EGFL6 expression was studied by immunohistochemical staining of specimens from 150 patients with lung adenocarcinoma. The correlation between clinicopathological features and EGFL6 expression was quantitatively analysed. We used Kaplan-Meier analysis and Cox proportional hazard models to examine the prognostic value of EGFL6 in terms of overall survival.

    Results No significant correlation was found between EGFL6 expression and clinical parameters. However, patients with high levels of EGFL6 expression showed a tendency towards poor prognosis, with borderline statistical significance. Grouping the patients according to a medium age value revealed a significant association between high EGFL6 expression and poor clinical outcome in young patients. This finding was further confirmed by grouping the patients into three groups according to age. HR in patients with high EGFL6 expression was higher in younger patients than in older patients.

    Conclusion High EGFL6 expression may serve as a marker for poor prognosis of lung adenocarcinoma, especially in younger patients.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/21657
    關聯: BMJ Open 2018 June 22, Volume 8, Issue 6., e021385
    显示于类别:[醫學系] 期刊論文

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