Impacts of AURKA Genetic Polymorphism on Urothelial Cell Carcinoma Development

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/21629

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题名:	Impacts of AURKA Genetic Polymorphism on Urothelial Cell Carcinoma Development
作者:	Chia-Hung Huang;Chih-Jung Chen;Pei-Ni Chen;Shian-Shiang Wang;Ying-Erh Chou;Sheng-Chun Hung;Shun-Fa Yang
关键词:	urothelial cell carcinoma;Aurora kinase A;susceptibility;single nucleotide polymorphism
日期:	2019-02-23
上传时间:	2021-08-17T02:23:29Z (UTC)
出版者:	Ivyspring International Publisher
摘要:	Urothelial cell carcinoma (UCC) is the most common primary malignancy of the urinary system and the second-most common type of renal cell carcinoma. Aurora kinase A (AURKA), a serine/threonine kinase, has a critical role in centrosome duplication, spindle assembly checkpoint, and cytokinesis. Here, we determined the correlation between UCC susceptibility and AURKA polymorphisms. We used real-time polymerase chain reaction to compare the genotype distributions and allelic frequencies of four single-nucleotide polymorphisms (SNPs) of AURKA, namely rs1047972, rs2273535, rs2064863, and rs6024836, between 431 UCC cases and 862 healthy controls. Logistic regression models demonstrated that the G allele of rs2064863, a genetic polymorphism of AURKA, exhibited a significant protective effect against UCC among the 862 nonsmokers. Moreover, patients with rs2064863 G allele exhibited a slightly lower risk of lymph node metastasis and those with rs6024836 G allele exhibited a lower risk of distant metastases. Our study suggested that several variants of AURKA SNPs rs2064863 and rs6024836 may serve as critical predictors for the clinical status of UCC.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/21629
關聯:	J Cancer 2019, 10(6),p.1370-1374
显示于类别:	[醫學系] 期刊論文

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