中山醫學大學機構典藏 CSMUIR:Item 310902500/21625
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    题名: Cytoplasmic, nuclear, and total PBK/TOPK expression is associated with prognosis in colorectal cancer patients: A retrospective analysis based on immunohistochemistry stain of tissue microarrays
    作者: Tzu-Cheng Su;Chun-Yu Chen;Wen-Che Tsai;Hui-Ting Hsu;Hsu-Heng Yen;Wen-Wei Sung;Chih-Jung Chen
    日期: 2018-10-04
    上传时间: 2021-08-17T02:06:33Z (UTC)
    出版者: PLOS
    摘要: Objective: PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) regulates components of the cell cycle, including cell growth, immune responses, DNA damage repair, apoptosis, and inflammation. PBK/TOPK may also accelerate tumorigenesis in colorectal cancer.

    Methods: We investigated the impact of PBK/TOPK on the clinical outcome of colorectal cancer patients to further identify its role in colorectal cancer. PBK/TOPK immunoreactivity was analyzed by immunohistochemistry in 162 cancer specimens from primary colorectal cancer patients.

    Results: The mean follow-up time after surgery was 5.4 years (medium: 3.9 years; range 0.01 to 13.1 years). The prognostic value of PBK/TOPK on overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. PBK/TOPK was expressed in both the cytoplasm and nucleus. High PBK/TOPK expression in tumor cells was significantly associated with advanced T value. The 5-year survival rate was greater for patients with high total PBK/TOPK expression than with low PBK/TOPK expression (58.3% vs 34.4%, P = 0.005). Multivariate analyses showed that low-scoring cytoplasmic PBK/TOPK, negative nuclear PBK/TOPK, low total PBK/TOPK, and advanced tumor stage were correlated with poor overall patient survival.

    Conclusions: We suggest that PBK/TOPK expression, detected by IHC staining, could be used as an independent prognostic marker for colorectal cancer patients.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/21625
    關聯: PLoS ONE, 13(10), e0204866.
    显示于类别:[醫學系] 期刊論文

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