中山醫學大學機構典藏 CSMUIR:Item 310902500/21593
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    請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21593


    題名: Kaempferol inhibits the cell migration of human hepatocellular carcinoma cells by suppressing MMP-9 and Akt signaling
    作者: Po-Chung Ju;Yung-Chuan Ho;Pei-Ni Chen;Hsiang-Lin Lee;Szu-Yu Lai;Shun-Fa Yang;Chao-Bin Yeh
    貢獻者: 中山醫學大學;醫研所
    關鍵詞: HCC;kaempferol;migration;MMP-9
    日期: 2021-06-22
    上傳時間: 2021-08-11T05:44:48Z (UTC)
    出版者: John Wiley & Sons, Inc.
    ISSN: 1520-4081
    摘要: Metastasis is the most prevalent cause of cancer-related deaths and treatment failure in patients with hepatocellular carcinoma (HCC). Kaempferol is a natural flavonol belonging to the subgroup of flavonoids and exhibits potent anticancer activities. This study provides molecular evidence on the anti-invasive and anti-migratory effects of kaempferol on human HCC cells. The anti-invasive effect was investigated by applying kaempferol on two human HCC cell lines (Huh-7 and SK-Hep-1). Kaempferol reduced the invasion and migration of Huh-7 and SK-Hep-1 cells by Boyden chamber invasion assay and wound healing assay, respectively. A protease array analysis showed that Matrix Metalloproteinase-9 (MMP-9) was dramatically downregulated in HCC cells after kaempferol treatment. Gelatin zymography and Western blot assay showed that kaempferol reduced the activities and protein expression of MMP-9, respectively. Kaempferol also sufficiently suppressed the phosphorylation of the Akt expression. Overall, kaempferol inhibited the invasive properties of human HCC cells by targeting MMP-9 and Akt pathways. Hence, kaempferol could be used as an adjuvant therapeutic agent for the treatment of human HCC cells.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/21593
    關聯: Environmental Toxicology
    顯示於類別:[醫學研究所] 期刊論文

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