Magnesium lithospermate B supplementation improved prenatal Bisphenol A exposure-induced metabolic abnormalities in male offspring

doi:doi.org/10.1002/tox.23313

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學研究所 > 期刊論文 > Item 310902500/21588

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题名:	Magnesium lithospermate B supplementation improved prenatal Bisphenol A exposure-induced metabolic abnormalities in male offspring
作者:	Huang, Wei-Chi Liao, Keng-Ying Hsieh, Sheng-Kuo Pan, Ping-Ho Kuan, Yu-Hsiang Liao, Su-Lan Chen, Chun-Jung Chen, Wen-Ying
贡献者:	中山醫學大學;醫研所
关键词:	Bisphenol A;endocrine-disrupting chemical;magnesium lithospermate B;metabolic abnormalities;nutraceutical
日期:	2021-06-24
上传时间:	2021-08-11T04:07:46Z (UTC)
出版者:	John Wiley & Sons, Inc.
ISSN:	1520-4081
摘要:	Obesity is closely linked with metabolic diseases, while life and prenatal exposure to endocrine-disrupting chemicals has been implicated in the development of obesity. Magnesium lithospermate B (MLB), an active compound of Salvia miltiorrhiza (Danshen), has beneficial effects on insulin resistance and metabolic abnormalities in diet-induced obese rodents. Since exposure to endocrine-disrupting chemical Bisphenol A (BPA) during pregnancy mimics the effects of high fat diet-induced alterations of glucose and lipid metabolism in adult male offspring, the effects of daily MLB supplementation for 4 weeks on metabolic abnormalities in rats weaning from prenatal BPA-exposed dams were investigated. BPA-exposed rats developed obesity and adiposity concurrent with hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia, and elevation of circulating glucagon and free fatty acids. Increased hepatic fatty acid synthesis and decreased fatty acid beta-oxidation, activation of adipocytic adipogenesis, maturation, and lipogenesis, as well as reduction of muscular glucose uptake were demonstrated in BPA-exposed rats. The aforementioned alterations were improved by MLB supplementation. Additionally, MLB displayed negative effects on glucocorticoid receptor action and inflammation, and promoted lipolysis and thermogenesis in the adipose tissues. In conclusion, our findings suggest that MLB may be a potential therapeutic compound against metabolic diseases, including maternal exposure-induced metabolic abnormalities.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/21588
關聯:	ENVIRONMENTAL TOXICOLOGY
显示于类别:	[醫學研究所] 期刊論文

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