中山醫學大學機構典藏 CSMUIR:Item 310902500/21090
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    题名: Duchesnea indica extract attenuates oral cancer cells metastatic potential through the inhibition of the matrix metalloproteinase-2 activity by down-regulating the MEK/ERK pathway
    作者: Wei-En Yang;Cheng-Ming Tang;Yih-Shou Hsieh;Pei-Ni Chen;Chih-Ting Lai;Shun-Fa Yang;Chiao-Wen Lin
    贡献者: 口腔科學研究所
    关键词: Metastasis;MMP-2;Oral cancer;DUCHESNEA indica
    日期: 2019-10
    上传时间: 2020-08-13T04:36:10Z (UTC)
    出版者: Phytomedicine
    摘要: Abstract
    Background
    Duchesnea indica (Andr.) Focke, an herb in folk medicine used extensively in traditional Chinese medicine, has cytostatic properties as well as antioxidant and antimetastasis activities in various cancer cells. However, the effects and underlying mechanisms of Duchesnea indica extracts (DIEs) on human oral squamous cell carcinoma (OSCC) metastases remain unclear.

    Purpose
    In this study, we posit the hypothesis that DIE possesses antimetastatic effects on human OSCC cells.

    Methods
    The effects of DIE on cell viability, motility, migration, and invasion were investigated. Gelatin zymography, Western blotting, migration and invasion assays were used to further study the underlying mechanisms involved in the antimetastatic effects of DIE in OSCC cells.

    Results
    The results from MTT assay revealed that DIE did not affect the cell viability of OSCC cells. Moreover, DIE significantly attenuated OSCC cells’ motility, migration, and invasion by reducing the MMP-2 protein expression and MMP-2 activity in a dose-dependent manner. In addition, DIE reduced the phosphorylation of both ERK1/2 and its upstream kinase but had no effect on the phosphorylation of p38 and JNK.

    Conclusion
    DIE triggers the antimetastatic activity in OSCC cells by suppressing the MMP-2 activity via the MEK/ERK signaling pathways. Therefore, these findings are promising for the use of DIE antimetastatic activity in oral cancer metastasis treatment.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21090
    關聯: Phytomedicine Volume 63, October 2019, 152960
    显示于类别:[口腔科學研究所] 期刊論文

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