中山醫學大學機構典藏 CSMUIR:Item 310902500/21087
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 17918/22933 (78%)
造訪人次 : 7433283      線上人數 : 152
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋


    請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21087


    題名: Prominent Vascularization Capacity of Mesenchymal Stem Cells in Collagen–Gold Nanocomposites
    作者: Shu-Chen Hsieh;Hui-Jye Chen;Shan-hui Hsu;Yi-Chin Yang;Cheng-Ming Tang;Mei-Yun Chu;Pei-Ying Lin;Ru-Huei Fu;Mei-Lang Kung;Yun-Wen Chen;Bi-Wen Yeh;Huey-Shan Hung
    貢獻者: 口腔科學研究所
    關鍵詞: mesenchymal stem cells, collagen−gold nanocomposites, stromal-derived factor-1α, vascular endothelial growth factor, vascular regeneration
    日期: 2016-10-07
    上傳時間: 2020-08-13T04:16:43Z (UTC)
    出版者: ACS Appl. Mater.
    摘要: ABSTRACT: The ideal characteristics of surface modification on the vascular
    graft for clinical application would be with excellent hemocompatibility,
    endothelialization capacity, and antirestenosis ability. Here, Fourier transform
    infrared spectroscopy (FTIR), surface enhanced Raman spectroscopy (SERS),
    atomic force microscopy (AFM), contact angle (θ) measurement, and
    thermogravimetric analysis (TGA) were used to evaluate the chemical and
    mechanical properties of collagen−gold nanocomposites (collagen+Au) with
    17.4, 43.5, and 174 ppm of Au and suggested that the collagen+Au with 43.5
    ppm of Au had better biomechanical properties and thermal stability than pure
    collagen. Besides, stromal-derived factor-1α (SDF-1α) at 50 ng/mL promoted
    the migration of mesenchymal stem cells (MSCs) on collagen+Au material
    through the α5β3 integrin/endothelial oxide synthase (eNOS)/metalloproteinase (MMP) signaling pathway which can be abolished by the knockdown of
    vascular endothelial growth factor (VEGF). The potentiality of collagen+Au
    with MSCs for vascular regeneration was evaluated by our in vivo rat model system. Artery tissues isolated from an implanted
    collagen+Au-coated catheter with MSCs expressed substantial CD-31 and α-SMA, displayed higher antifibrotic ability,
    antithrombotic activity, as well as anti-inflammatory response than all other materials. Our results indicated that the implantation
    of collagen+Au-coated catheters with MSCs could be a promising strategy for vascular regeneration.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21087
    關聯: ACS Appl. Mater. Interfaces 2016, 8, 28982−29000
    顯示於類別:[口腔科學研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    10.pdf3223KbAdobe PDF255檢視/開啟


    檢視Licence

    SFX Query

    在CSMUIR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋